Hostname: page-component-8448b6f56d-m8qmq Total loading time: 0 Render date: 2024-04-23T08:18:16.841Z Has data issue: false hasContentIssue false

A Causal Link Between Handwashing and Risk of Infection? Examination of the Evidence

Published online by Cambridge University Press:  02 January 2015

Elaine Larson*
Affiliation:
Johns Hopkins University School of Nursing, Baltimore, Maryland
*
Nutting Chair in Clinical Nursing, The Johns Hopkins School of Nursing, Baltimore, MD 21205

Abstract

To examine evidence of a causal link between handwashing and risk of infection, a review of published literature from 1879 through 1986 was conducted. In the 107 years studied, 423 articles specifically related to handwashing were found. Articles were categorized as studies to evaluate products (50.8%), review articles (29.1%), behavioral studies (10.9%), methodologie studies (2.8%), studies linking handwashing to infection and other (3.1%). There was an increase in the proportion of handwashing articles published in the 1980s with the rate (9.4/105 citations/year) being almost double that of any other period studied. Nonexperimental and experimental studies related to handwashing were reviewed and evidence for a causal association evaluated. Except for specificity, all the elements for causality, including temporality, strength, plausibility, consistency of the association, and dose response were present. It was therefore concluded that emphasis on handwashing as a primary infection control measure has not been misplaced and should continue.

Type
Original Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Ayliffe, GAJ; Nosocomial infection—The irreducible minimum. Infect Control 1986: 7:9295.Google ScholarPubMed
2.Steere, AC, Mallison, GF: Handwashing practices for the prevention of nosocomial infections. Ann Intern Med 1975; 83:683690.Google Scholar
3.Larson, E: Handwashing and skin: Physiologic and bacteriologic aspects. Infect Control 1985: 6:1423.Google Scholar
4.Lilly, HA, Lowbury, EJL: Transient skin flora. J Clin Pathol 1978; 31:919922.Google Scholar
5.Garner, JS, Favero, MS: Guideline for Handwashing and Hospital Environmental Control, 1985. Atlanta, Centers for Disease Control, 1985.Google Scholar
6.Soule, BM (ed): The APIC Curriculum for Infection Control Practice. Dubuque, Iowa, Kendall/Hunt Publishing Company, 1983.Google Scholar
7.Albert, RK, Condie, F: Handwashing patterns in medical intensive care units. N Engl J Med 1981; 304:14651466.Google Scholar
8.Larson, E, Killien, M, Factors influencing handwashing behavior of patient care personnel. Am J Infect Control 1982; 10:9399.Google Scholar
9.Preston, GV, Larson, EL, Stanun, WE: The ef fect of private isolation rooms on patient are practices, colonization and infection in an intensive care unit. Am J Med 1980; 70:641645.CrossRefGoogle Scholar
10.Taylor, LJ: An evaluation of handwashing techniques. Nurs Times 1978; 74:5455.Google Scholar
11.Kaplan, LM, McGuckin, MA: Increasing handwashing compliance with more accessible sinks. Infect Control 1980; 7:408410.CrossRefGoogle Scholar
12.Mayer, JA, Dubbert, PM, Miller, M, et al: Increasing handwashing in an intensive care unit. Infect Control 1980; 7:259262.CrossRefGoogle Scholar
13.Geller, ES, Eason, SL, Phillips, JA. et al: Interventions to improve sanitation during food preparation. J Organizet Behav Managem 1980; 2:229240.Google Scholar
14.Nauseef, WM, Maki, DG: A study of the value of simple protective isolation in patients with granulocytopenia. N Engl J Med 1981; 304:448453.Google Scholar
15.Jacksou, MM: From ritual to reason—With a rational approach for the future. Am J Infect Control 1984; 12:213220.CrossRefGoogle Scholar
16.Maki, DG, Alvarado, C, Hassemer, C: Double-bagging of items from isolation rooms is unnecessary as an infection control measure: A comparative study of surface contamination with single- and double-bagging. Infect Control 1980; 7:535537.Google Scholar
17.Murphy, D, Todd, JK, Chao, RK, The use of gowns and masks to control respiratory illness in pediatric hospital personnel. J Pediati 1981; 99:746750.Google Scholar
18.Donowitz, LG: Failure of the overgown to prevent nosocomial infection in a pediatric intensive care unit. Pediatrics 1980; 77:3538.CrossRefGoogle Scholar
19.Evans, HE, Akpata, SO, Baki, A: Bacteriologic and clinical evaluation of gowning in a premature nursery. J Pediatrics 1971; 78:883886.Google Scholar
20.Blake, JB (ed): Centenary of Index Medicus, 1879-1979. Bethesda, National Library of Medicine, 1980, pp 5355.Google Scholar
21.Miles, WD: A History of the National Library of Medicine. Bethesda, National Library of Medicine. 1982. p 382.Google Scholar
22.Wiuslow, CEA: The occurrence of the colon bacillus on the hands. J Med Res 1903; 10:463471.Google Scholar
23.Barker, AEJ: The hands of surgeons and assistants in operations. Lancet 1906: 2:345348.Google Scholar
24.Williamson, JR: Sterilization of the hands. Br Med J 1904; 1:11331134.Google Scholar
25.Breiter, N: The hand as a promotion of microbic disease—A medico-social question. Med Rec 1897; 52:813816.Google Scholar
26.McBride, ME, Montes, LF, Fahlberg, WJ, et al: Microbial flora of nurses' hands. Intern J Dermatol 1972; 11:4953.Google Scholar
27.Price, PB: The bacteriology of normal skin. J infect Dis 1938; 63:301318.CrossRefGoogle Scholar
28.Hann, JB: The source of the ‘resident’ flora. Hand 1973; 5:247252.Google Scholar
29.Marples, M: The Ecology of the Human Skin. Springfield, Charles C. Thomas, 1905.Google Scholar
30.Larson, EL: Persistent carriage of gram-negative bacteria on hands. Am J infect Control 1981; 9:112119.Google Scholar
31.Larson, E, Leyden, JJ, McGinley, KJ, et al: Physiologic and microbiologic changes in skin related to frequent handwashing. Infect Control 1980; 7:5963.Google Scholar
32.Noble, W: Skin asa source for hospital infection. Infect Control 1980; 7:111112.Google Scholar
33.Galabin, AL: The prevention and treatment of puerperal septicaemai. Clin J (London) 1987; 11:4957.Google Scholar
34.Shoemaker, GE: The prevalence and the prevention of puerperal infection in private practice. Therap Gaz 1898; 22:809813.Google Scholar
35.Matousek, WJ: Contamination of the hands and other objects in the spread of contagious diseases. JAMA 1921: 70:14901491.Google Scholar
36.Weaver, GH, Murchi, JT: Contamination of the hands and other objects in the spread of diphtheria. JAMA 1919; 73:19211922.CrossRefGoogle Scholar
37.Hill, HW, Mathews, HM: Transfer of infection by handshakes. Publ Health J 1920; 17:347352.Google Scholar
38.Marples, RR, Lowers, AG: A laboratory model for the investigation of contact transfer of micro-organisms. J Hyg (Camb) 1979; 82:237248.Google Scholar
39.Orskov, I: Nosocomial infection with Klebsiella in lesions of the urinary tract. Acta Pathol Microbiol Immunol Scand 1954; 35:194–190.CrossRefGoogle ScholarPubMed
40.Adler, JL, Shulman, JA, Terry, PM, et al: Nosocomial colonization with kanamycin-resistant Klebsiella pneumoniae types 2 and 11 in a premature nursery. J Pediatr 1970; 77:370380.Google Scholar
41.Saltzman, TC, Clark, JJ, Klemm, L: Hand contamination of personnel as a mechanism of cross-infection in nosocomial infections with antibiotic-resistant Escherichia coli and Klebsiella-Aerobacter. Antimicrob Agents Chemo 1908, pp 97100.Google Scholar
42.Kominos, SD, Copeland, CE, Grosiak, B: Mode of transmission of Pseudomonas aeruginosa in a burn unit and an intensive care unit in a general hospital. Appl Microbiol 1972; 23:309312.Google Scholar
43.Knittle, MA, Eitzman, DV, Baer, H: Role of hand contamination of personnel in the epidemiology of gram-negative nosocomial infections. J Pediatr 1975: 80:433437.CrossRefGoogle Scholar
44.Bruun, J, Solberg, C: Hand carrigae of gram-negative bacilli and Staphylococcus aureus. Br Med J 1973; 2:580582.CrossRefGoogle ScholarPubMed
45.Sprun, K. Redman, W, Leidy, G: Antibacterial effectiveness of routine handwashing. Pediatrics 1973; 52:204271.Google Scholar
46.Casewell, MW, Phillips, I: Hands as a route of transmission of Klebsiella species. Br Med J 1977: 2:13151317.Google Scholar
47.Casewell, MW: The role of hands in nosocomial gram-negative infection, in Maibach, H, Aly, R (eds): Skin Microbiology: Relevance to Clinical Infection. New York, Springer-Verlag, 1981. pp 192202.Google Scholar
48.Casewell, MW, Desai, N: Survival of multiply resistant Klebsiella aerogenes and other gram-negative bacilli on fingertips. J Hosp Infect 1983; 4:350360.Google Scholar
49.Hart, CA, Gibson, MF, Buckles, AM: Variation in skin and environmental survival of hospital gentamicin-resistant enterobacteria. J Hyg (Camb) 1981; 87:277284.CrossRefGoogle ScholarPubMed
50.Parry, MR, Hutchinson, JH, Brown, NA, et al: Gram-negative sepsis in neonates: A nursery outbreak due to hand carriage of Citrobacter diversus. Pediatrics 1980; 65:11051109.Google Scholar
51.Buxton, AE, Anderson, RL, Werdegar, D, et al: Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus. Am J Med 1978; 65:507513.Google Scholar
52.Vishniavsky, N, Archer, G: The epidemiology of antibiotic-resistant coagulase-negative staphylococci in a cardiac surgery unit. Abstracts of the 1984 Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC: 1984, p 175.Google Scholar
53.Gwaltney, JM, Moskalski, Hendley JO: Hand-to-hand transmission of rhinovirus colds. Ann Intern Med 1978; 88:463467.Google Scholar
54.Hall, CB, Douglass, RG, Gieman, JM: Possible transmission by fomites of respiratory syneytial virus. J Infect Dis 1980; 141:98102.Google Scholar
55.Burnie, J: Candida and hands. J Hasp Infect 1980; 8:14.Google Scholar
56.Schurmann, W, Eggers, HJ: An experimental study on the epidemiology of enteroviruses: Water and soap washing of poliovirus l-contaminated hands, its effectiveness and kinetics. Med Microbiol Immunol 1985; 174:221236.Google Scholar
57. Editorial. Bactermia tied to overcrowding, overtime and decreased handwashing. Hosp Infect Control 1980; 7:6162.Google Scholar
58.Cruse, PJE, Foord, R: A five-year prospective study of 23,049 surgical wounds. Arch Surg 1973; 107:206210.CrossRefGoogle Scholar
59.Kaslow, RA, Dixon, RE, Martin, SM, et al: Staphylococcal disease related to hospital nursery bathing practices—A nationwide epidemiological investigation. Pediatrics 1973; 51:418425.Google Scholar
60.Hargiss, C, Larson, E: The epidemiology of Staphylococcus aureus in a newborn nursery from 1970-1970. Pediatrics 1978; 61:348353.Google Scholar
61.Hyams, PJ, Counts, GW, Monkus, E, et al: Staphylococcal bacteremia and hexachlorophene bathing. Am J Dis Child 1975; 129:595.Google Scholar
62.Godlee, R: Six Papers by Lord Lister with a Short Biography. London, John Bale, Sons and Danielsson, Ltd, 1921.Google Scholar
63.Lister, J: On a new method of treating compound fractures, abscesses, etc. Lancet 1867; 1:326, 357, 387, 507: 2:95.Google Scholar
64.Towne, GS: Listerism: Its past, present and future. NY Med J 1903; 78:453–450.Google Scholar
65.Keen, WW: Before and after Lister. Science 1915; 61:846853.Google Scholar
66.Orr, HW: The development of the concept of antisepsis and asepsis from Lister to World War II. Int Abst Surg 1947; 85:209223.Google Scholar
67.Bland-Sutton, J: The conquest of sepsis. Lancet 1927; 1:781.Google Scholar
68.Ashhust, APC: The centenary of Lister (1827-1927): A tale of sepsis and antisepsis. Trans Coll Phys 1927; 49:7093.Google Scholar
69.Keen, WW: Modern antiseptic surgery and the role of experimentation in its discovery and development. JAMA 1910: 54:11041109.Google Scholar
70.Traub, EF, Newhall, CA, Fuller, JR: The value of a new compound used in soap to reduce the bacterial flora of the human skin. Surg Gynecol Obstet 1944; 79:205207.Google Scholar
71.Leonard, RR: Prevention of superficial cutaneous infections. Arch Dermatol 1967; 95:520523.Google Scholar
72.Duncan, WC, Dodge, BG, Knox, JM: Prevention of superficial pyogenic skin infections. Arch Dermatol 1969; 99:465468.Google Scholar
73.MacKenzie, AR: Effectiveness of antibacterial soaps in a healthy population. JAMA 1970; 211:973976.Google Scholar
74.Taplin, D: Antibacterial soaps: Chlorhexidine and skin infections, in Maibach, H, Aly, R (eds): Skin Microbiology: Relevance to Clinical Infection. New York, Springer-Verlag. 1981, pp 113125.Google Scholar
75.Lowbury, EJL: Removal of bacteria from the operation site, in Maibach, HI, Hildrick-Smith, G (eds): Skin Bacteria and Their Role in Infection. New York, McGraw-Hill. 1965, pp 263275.Google Scholar
76.Brandberg, A, Holm, J, Hammarsten, J, et al: Postoperative wound infections in vascular surgery: Effect of preoperative whole body disinfection by shower-bath with Chlorhexidine soap, in Malbach, H, Aly, R (eds): Skin Microbiology: Relevance to Clinical Infection. New York, Springer-Verlag, 1981, pp 98102.Google Scholar
77.Ayliffe, GAJ: Surgical scrub and skin disinfection. Infect Control 1984; 5:2327.Google Scholar
78.Gezon, HM, Thompson, DJ, Rogers, KD, et al: Hexachlorophene bathing in early infancy. Effect on staphylococcal disease and infection. N Engl J Med 1964; 270:379380.Google Scholar
79.Simon, HJ: Prevention of staphylococcal infection and cross-infection among newborn infants, in Maibach, HI, Hildrick-Smith, G (eds): Skin Bacteria and Their Role in infection. New York, McGraw-Hill, 1965, pp 253–201.Google Scholar
80.Holmes, OW: The contagiousness of puerperal fever. N Engl Quar J Med Surg 1843; 1:503530.Google Scholar
81.Campbell, W: A Treatise on the Epidemic Puerperal Fever. Edinburgh, Bell and Bradfute. 1822.Google Scholar
82.Wiese, ER: Semmelweis. Ann Med Hist 1930; 2:8088.Google Scholar
83.Carter, KC: Semmelweis and his predecessors. Med Hist 1981; 25:5772.Google Scholar
84.Sprigge, SS: Oliver Wendel Holmes and the doctrine of Semmelweis. Lancet 1909; 2:882.Google Scholar
85.Miller, PJ: Seinmelweiss. Infect Control 1982; 3:405409.Google Scholar
86.Herdegcn, R: Ignaz Philip Seinmelweiss: A biographical sketch. Am J Obstetr 1885; 18:248255.Google Scholar
87.Walter, CW: Handwashing and Semmelweiss (letter). Ann Intern Med 1967; 85:398.CrossRefGoogle Scholar
88.Semmelweiss, IP: The Etiology, the Concept and the Prophylaxis of Childbed Fever. Pest. Hungary, CA Hartleben's Verlag-Expedition. 1861 (Translation by Murphy, FP republished Classics of Medicine Library, Birmingham, 1981).Google Scholar
89.Wolinsky, E, Lipsitz, PJ, Mortimer, EA, et al: Acquisition of staphylococci by newborns: Direct versus indirect transmission. Lancet 1960; 2:620622.Google Scholar
90.Mortimer, EA, Lipsitz, PJ, Wolinsky, E, et al: Transmission of staphylococci between newborns. Am J Dis Child 1962; 104:289295.Google Scholar
91.Mortimer, EA, Wolinsky, E, Gonzaga, AJ, et al: Role of airborne transmission in staphylococcal infectious. Br Med J 1966; 1:319322.Google Scholar
92.Rammelkamp, CH, Mortimer, EA, Wolinsky, E. Treatment of streptococccal and staphylococcal infections. Ann Intern Med 1964: 60:753758.Google Scholar
93.Maki, DG, Hecht, J: Antiseptic-containing handwashing agents reduce nosocomial infections—A prospective study. Proceedings of the Twenty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami Beach; 1982. p 303A.Google Scholar
94.Massanari, RM, Hierholzer, WJ: A crossover comparison of antiseptic soaps on nosocomial infection rates in intensive tare units (abstract). Am J Infect Control 1984; 12:247–218.Google Scholar
95.Black, RE, Dykes, AC, Anderson, KE, et al: Handwashing to prevent diarrhea in day-care centers. Am J Epidemiol 1981; 113:445451.Google Scholar
96.Khan, MU: Interruption of shigellosis by handwashing. Trans R Soc Trop Med Hyg 1982; 70:164168.Google Scholar
97.Shahid, NS, Greenough, WB, Samadi, AR, et al: Handwashing with soap reduces diarrhea and spread of pathogens in Bangladesh village (unpublished manuscript).Google Scholar
98.Nightingale, F: Notes on Nursing: What It Is, and What It Is Not. London, Harrison. 1959.Google Scholar
99.Nightingale, F: Notes on Hospitals, ed 3. London. Longman, Green, Longman. Roberts, and Green, 1863.Google Scholar
100.Nightingale, F: Introductory Notes on Lying-in Institutions. London. Longmans, Green, and Company. 1871.Google Scholar
101.Maki, DG: Skin as a source of nosocomial infection: Directions for future research. Infect Control 1980; 7:113116.Google Scholar