PT - JOURNAL ARTICLE AU - Antonietta Giannattasio AU - Andrea Lo Vecchio AU - Fabio Albano AU - Vania Giacomet AU - Alessandro Barbarino AU - Alfredo Guarino TI - Flu and pneumococcal immunisations in HIV-infected children: methodological quality of current recommendations AID - 10.1136/bmjqs.2010.047316 DP - 2011 May 01 TA - BMJ Quality & Safety PG - 432--439 VI - 20 IP - 5 4099 - http://qualitysafety.bmj.com/content/20/5/432.short 4100 - http://qualitysafety.bmj.com/content/20/5/432.full SO - BMJ Qual Saf2011 May 01; 20 AB - Objective To assess the quality of guidelines, consensus statements and systematic reviews on flu and pneumococcal immunisations in HIV-infected children.Method The authors screened PubMed and Embase databases until the year 2009 for guidelines, consensus statements and systematic reviews on flu and pneumococcal immunisations in HIV-infected patients. The authors also explored relevant websites of agencies/institutions involved with HIV infection, immunisation or guidelines. The Appraisal of Guidelines for Research and Evaluation instrument and the checklists of the Scottish Intercollegiate Guidelines Network were used to evaluate the scientific quality of guidelines and systematic reviews.Results Eighteen articles were identified. Only one guideline was of good overall quality. Generally the weakest domains were ‘Applicability’ and ‘Editorial Independence.’ Although of poor methodological quality, the main recommendations on flu and pneumococcus vaccinations were similar. There were minor differences in the type of pneumococcal vaccines in relation to patient's age, namely based on the settings in which recommendations were produced.Conclusions Although guidelines and systematic reviews on flu and pneumococcal vaccination in HIV-infected children came from authoritative institutions, their overall quality is poor, with the weakest fields being the methodological domains.