Laboratory triggers
| Laboratory triggers | Drugs |
|---|---|
| Anemia | Antiplatelet agents, antithyroid agents, oral steroids, lithium, niacin, nsaids, warfarin |
| Leukocytopenia | Carbamazepine, clozapine, ganciclovir |
| Thrombocytopenia | Diuretics, H2 blockers, procainamide, quinidine, sulfonamide, sulfonamide antibiotics, ticlopidine |
| Raised bilirubin | Cyclosporine |
| Raised bilirubin and ALP | Allopurinol, amoxicillin/clavulanate, azathioprine, chlorpromazine, chlorpropamide, tolazamide, tolbutamide |
| Raised ALT or AST | Amiodarone, atorvastatin, carbamazepine, celecoxib, cerivastatin, cyclophosphamide, divalproex, erthromycin estolate, fluoxetine, fluvastatin, ibuprofen, isoniazide, lovastatin, methotrexate, methyldopa, metformin, nefazodone, nevirapine, paroxetine, pioglitazone, pravastatin, rifampin, ritonavir, rofecoxib, rosiglitazone, sertraline, simvastatin, sulfamethoxasole, sulfasalazine, sulfisoxazole, tetracycline, valproic acid, venlafaxine |
| Hyperkalemia | ACE inhibitors, COX II inhibitors, NSAIDs, potassium sparing diuretics, potassium supplement, trimethoprim |
| Hypokalemia | Digoxin, non-potassium sparing diuretics |
| Hyponatremia | Diuretics |
| Hyperglycemia | Oral steroids |
| Hypoglycemia | Hypoglycemics, insulin |
| Raised creatinine | ACE inhibitors, allopurinol, ARBs, atenolol, azathioprine, cyclosporine, digoxin, diuretics, enoxaparin, ganciclovir, metformin, NSAIDs, procainamide, tacrolimus |
| Raised BUN | Diuretics |
| Falling TSH | Levethyroxine |
| Raised CPK | HMG-COA reductase inhibitors |
| Positive UHCG for female aged <45 | Atorvastatin, benazepril, captopril, cerivistatin, clozapine, clomiphene, danazol, desogestrel, dienestrol, diethystilbesterol, dihydroergotamine, enalapril, ephedrine, ergotamine, estazolam, estradiol, estrogens conjugated, estrogens, esterified, estrone, estropipate, ethinyl estradiol, etretinate, finesteride, fluoxymersterone, fluvastatin, fosinopril, goserelin, isotretinoin, levonorgestrel, lisinopril, lovastatin, medroxyprogesterone, megestrol, mestranol, methotrexate, methyltestosterone, misoprostol, moexipril, naferelin, nandrolone, norethinadrone, norgestrel, oxandrolone, perindopril, pravastatin, quazepam, quinapril, quinestrol, quinine, ramipril, raloxefine, ribavirin, simvastatin, temazepam, testosterone, trandolapril, triazolam, urofollitropin, vitamin A, warfarin |
| Raised blood level | Lithium |
| Raised blood level or no test for 12 months | Carbamazepine, cyclosporine, digoxin, phenobarbital, primidone, phenytoin, procainamide, quinidine, theophylline, valproate |
| Raised INR | Warfarin |
| Positive fecal occult blood | Antiplatelet agents, antithyroid agents, oral steroids, lithium, niacin, NSAIDs, warfarin |
| Positive C difficile toxin or culture | Antibiotics |
| No WBC test for 1 month | Clozapine |
| No creatinine test for 3 months | Allopurinol, azathioprine |