ADE rates for baseline, transition, and post-intervention period
| Baseline | Transition | Post-intervention | p value | χ2 for trend | |
|---|---|---|---|---|---|
| ADE, adverse drug event; IQR, interquartile range; RR, relative risk compared with baseline; CI, confidence interval. | |||||
| *Only one chart per patient was used. | |||||
| Median (IQR) ADEs per 1000 doses dispensed | 2.04 (1.79–2.70) | 1.26 (0.21–1.53) | 0.65 (0.41–0.87) | 0.001 | |
| Median (IQR) ADEs per 100 patient days | 5.07 (3.79–6.02) | 3.19 (0.58–5.03) | 1.30 (0.87–1.71) | 0.001 | |
| ADEs per total doses delivered | 36/16829 doses | 18/15586 doses | 34/55988 doses | ||
| RR for ADE (95% CI) | 1.00 | 0.53 (0.30 to 0.94) | 0.28 (0.18 to 0.45) | <0.001 | 30.3 |
| ADEs per total number of patient days | 36/730 days | 18/593 days | 34/2604 days | ||
| RR for ADE (95% CI) | 1.00 | 0.63 (0.36 to 1.09) | 0.27 (0.17 to 0.44) | <0.001 | 34.1 |
| ADE severity F–I per total doses delivered | 10 | 7 | 4 | ||
| RR for ADE (95% CI) | 1.00 | 0.74 (0.28 to 1.95) | 0.12 (0.04 to 0.38) | <0.001 | 17.7 |
| Patients with ADEs per total number of charts reviewed* | 32/120 charts | 16/90 charts | 33/370 charts | ||
| RR for ADE (95% CI) | 1.00 | 0.67 (0.39 to 1.14) | 0.33 (0.22 to 0.52) | <0.001 | 25.0 |