| Intervention(n = 172)Patients (%) | Control(n = 96)Patients (%) | ARR* (%) | p Value | |
| Patient-related medical reasons (eg, change of patient’s condition) | 17 (9.7) | 15 (15.2) | −6.2 | 0.24 |
| Patient-related non-medical reasons | 16 (9.2) | 7 (7.2) | 0.05 | 0.99 |
| Physician-related medical reason (eg, disagreement with recommendation) | 8 (4.6) | 3 (3.5) | 0.6 | 0.93 |
| Cost (impact on drug budget of physician) | 5 (2.6) | 10 (10.7) | −7.4 | 0.052 |
| Other reasons | 1 (0.4) | 2 (1.8) | −1.9 | 0.24 |
*Adjusted absolute risk reduction; adjustment for differences in frequencies of medical conditions.