Drug or drug class | Prescribing discrepancies (n)* | ADEs (n) | Positive predictive value (n/n) (95% CI) | Example: discrepancy (ADE) |
Opioid analgesics | 54 | 15 | 0.28 (0.17 to 0.42) | Oxycodone omitted (pain) |
Metronidazole | 25 | 4 | 0.16 (0.05 to 0.37) | Metronidazole omitted (diarrhoea) |
Non-opioid analgesics | 37 | 5 | 0.14 (0.05 to 0.30) | Acetaminophen omitted (pain) |
Levothyroxine | 17 | 2 | 0.12 (0.02 to 0.38) | Levothyroxine omitted (constipation) |
Anti-prostate agents | 12 | 1 | 0.08 (0.00 to 0.35) | Terazosin omitted (urinary retention) |
Anti-arrhythmic agents | 13 | 1 | 0.08 (0.00 to 0.38) | Digoxin dose changed (elevated level) |
Nitrates | 43 | 3 | 0.07 (0.02 to 0.20) | Nitrate route change (hypotension) |
Warfarin | 45 | 3 | 0.07 (0.02 to 0.19) | Warfarin dose changed (thrombosis) |
Calcium blockers | 45 | 3 | 0.07 (0.02 to 0.19) | Felodipine omitted (hypertension) |
Benzodiazepines | 30 | 2 | 0.07 (0.01 to 0.24) | Clonazepam omitted (agitation) |
Angiotensin blockers | 80 | 5 | 0.06 (0.02 to 0.15) | Lisinopril increased (creatinine increase) |
Anti-epileptic agents | 53 | 3 | 0.06 (0.02 to 0.17) | Carbamazepine omitted (seizure) |
Insulin | 65 | 3 | 0.05 (0.01 to 0.14) | Insulin omitted (hyperglycaemia) |
Anti-psychotic agents | 55 | 2 | 0.04 (0.01 to 0.14) | Risperidone omitted (agitation) |
Laxatives | 80 | 3 | 0.04 (0.01 to 0.11) | Tegaserod omitted (constipation) |
Diuretics | 86 | 3 | 0.03 (0.01 to 0.11) | Furosemide dose increased (hypotension) |
Beta-blockers | 62 | 2 | 0.03 (0.01 to 0.12) | Metroprolol omitted (hypertension) |
Bronchodilators | 111 | 2 | 0.02 (0.00 to 0.07) | Albuterol omitted (dyspnoea) |
Proton-pump inhibitors | 123 | 2 | 0.02 (0.01 to 0.08) | Pantoprazole omitted (epigastric pain) |
Antibiotics†| 176 | 1 | 0.01 (0.00 to 0.04) | Antibiotic switch (angio-oedema) |
H2 blockers | 74 | 0 | 0.00 (0.00 to 0.06) | |
Oral hypoglycaemics | 64 | 0 | 0.00 (0.00 to 0.07) |
*Indicates prescribing omission, dose change, route change or switch to a new medication for the same indication. Drugs or drug classes are included that had at least 10 discrepancy occurrences. †Excluding metronidazole, which is shown separately.