Table 1 Predictive value of prescribing discrepancies for adverse drug events (ADEs)
Drug or drug classPrescribing discrepancies (n)*ADEs (n)Positive predictive value (n/n) (95% CI)Example: discrepancy (ADE)
Opioid analgesics54150.28 (0.17 to 0.42)Oxycodone omitted (pain)
Metronidazole2540.16 (0.05 to 0.37)Metronidazole omitted (diarrhoea)
Non-opioid analgesics3750.14 (0.05 to 0.30)Acetaminophen omitted (pain)
Levothyroxine1720.12 (0.02 to 0.38)Levothyroxine omitted (constipation)
Anti-prostate agents1210.08 (0.00 to 0.35)Terazosin omitted (urinary retention)
Anti-arrhythmic agents1310.08 (0.00 to 0.38)Digoxin dose changed (elevated level)
Nitrates4330.07 (0.02 to 0.20)Nitrate route change (hypotension)
Warfarin4530.07 (0.02 to 0.19)Warfarin dose changed (thrombosis)
Calcium blockers4530.07 (0.02 to 0.19)Felodipine omitted (hypertension)
Benzodiazepines3020.07 (0.01 to 0.24)Clonazepam omitted (agitation)
Angiotensin blockers8050.06 (0.02 to 0.15)Lisinopril increased (creatinine increase)
Anti-epileptic agents5330.06 (0.02 to 0.17)Carbamazepine omitted (seizure)
Insulin6530.05 (0.01 to 0.14)Insulin omitted (hyperglycaemia)
Anti-psychotic agents5520.04 (0.01 to 0.14)Risperidone omitted (agitation)
Laxatives8030.04 (0.01 to 0.11)Tegaserod omitted (constipation)
Diuretics8630.03 (0.01 to 0.11)Furosemide dose increased (hypotension)
Beta-blockers6220.03 (0.01 to 0.12)Metroprolol omitted (hypertension)
Bronchodilators11120.02 (0.00 to 0.07)Albuterol omitted (dyspnoea)
Proton-pump inhibitors12320.02 (0.01 to 0.08)Pantoprazole omitted (epigastric pain)
Antibiotics†17610.01 (0.00 to 0.04)Antibiotic switch (angio-oedema)
H2 blockers7400.00 (0.00 to 0.06)
Oral hypoglycaemics6400.00 (0.00 to 0.07)
  • *Indicates prescribing omission, dose change, route change or switch to a new medication for the same indication. Drugs or drug classes are included that had at least 10 discrepancy occurrences. †Excluding metronidazole, which is shown separately.