References
Guyatt G, Sackett D, Taylor D. Determining optimal therapy. Randomized trials in individual patients. N Engl J Med. 1986;314(14):889–92.
Larson EB, Ellsworth AJ, Oas J. Randomized clinical trials in single patients during a 2-year period. JAMA. 1993;270:2708–12.
Smith-Bindman R, Miglioretti DL, Larson EB. Rising use of diagnostic medical imaging in a large integrated healthcare system. Health Affairs. 2008;27(6):1491–1502. PMCID:PMC2765780.
Scuffham PA, Nikles J, Mitchell GK et al. Using N-of-1 trials to improve patient management and save costs. J Gen Intern Med 2010; DOI: 10.1007/s11606-010-1352-7.
Kravitz R, Duan N, Niedzinski E, Hay M, Subramanian S, Weisner T. What ever happened to N-of-1 trials? Insiders’ perspectives and a look to the future. Milbank Q. 2009;86(4):533–55.
Yelland M, Poulos C, Pillans P et al. N-of-1 randomized trials to assess the efficacy of gabapentin for chronic neuropathic pain. Pain Med. 2009;10(4):754–61.
Featherstone HJ, Beitman BD, Irby DM. Distorted learning from unusual medical anecdotes. Med Educ. 1984;18:155–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Larson, E.B. N-of-1 Trials: A New Future?. J GEN INTERN MED 25, 891–892 (2010). https://doi.org/10.1007/s11606-010-1440-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11606-010-1440-8