Background. Proliferating cell nuclear antigen (PCNA), a proliferation marker, epidermal
growth factor receptor (EGFR), a glycoprotein that plays a role in tumorigenesis by binding …

Background Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent
therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver …

Background The interim analysis of the multicentre New EPOC trial in patients with
resectable colorectal liver metastasis showed a significant reduction in progression-free …

The 'magic bullet'concept predicted over a century ago that antibodies would be used to
target cancer therapy. Since then initial problems that were related to specificity, purity and …

Introduction Intravenous medication administration has traditionally been regarded as error
prone, with high potential for harm. A recent US multisite study revealed few potentially …

Antibodies can be used to target cancer therapies to malignant tissue; the approach is
attractive because conventional treatments such as chemo-and radiotherapy are dose …

Background Little is known about patients' and carers' experiences of interacting with home
haemodialysis (HHD) technology, in terms of user experience, how the design of the …

Purpose: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a
tumor-targeted antibody-enzyme complex localizes in tumor for selective conversion of …

In radioimmunoguided surgery (RIGS), a radiolabeled antibody is given iv before surgery
and a hand-held gamma-detecting probe is used to locate tumor in the operative field. The …

Medical devices are becoming more interconnected and complex, and are increasingly
supported by fragmented organizational systems, eg through different processes …