While critically ill patients experience a life-threatening illness, they commonly contract
ventilator-associated pneumonia. This nosocomial infection increases morbidity and likely …

Pulmonary disease changes the physiology of the lungs, which manifests as changes in
respiratory mechanics. Therefore, measurement of respiratory mechanics allows a clinician …

Importance Experimental data suggest that intravenous vitamin C may attenuate
inflammation and vascular injury associated with sepsis and acute respiratory distress …

Background An update of evidence-based guidelines concerning liberation from mechanical
ventilation is needed as new evidence has become available. The American College of …

The institutional review board (IRB) is one part of the research enterprise designated to
protect human subjects. At times the IRB can feel like an oppressive oversight body bound …

PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic
resonance (MR) images of the lung in patients with emphysema and to determine whether …

Objective: It has been suggested that fluid accumulation may delay recognition of acute
kidney injury. We sought to determine the impact of fluid balance on the incidence of …

Background: Interventions that lead to earlier liberation from mechanical ventilation can
improve patient outcomes. This guideline, a collaborative effort between the American …

Thirty-two magnetic resonance imaging examinations of the lungs were performed in 16
subjects after inhalation of 1–2 L of helium 3 gas that was laser polarized to 10%–25%. The …

Background: This clinical practice guideline addresses six questions related to liberation
from mechanical ventilation in critically ill adults. It is the result of a collaborative effort …