The capsaicin receptor: a heat-activated ion channel in the pain pathway

MJ Caterina, MA Schumacher, M Tominaga, TA Rosen… - Nature, 1997 - nature.com
Capsaicin, the main pungent ingredient in 'hot'chilli peppers, elicits a sensation of burning
pain by selectively activating sensory neurons that convey information about noxious stimuli …

America's opioid epidemic: supply and demand considerations

DJ Clark, MA Schumacher - Anesthesia & Analgesia, 2017 - journals.lww.com
America is in the midst of an opioid epidemic characterized by aggressive prescribing
practices, highly prevalent opioid misuse, and rising rates of prescription and illicit opioid …

The ACTTION–APS–AAPM Pain Taxonomy (AAAPT) multidimensional approach to classifying acute pain conditions

ML Kent, PJ Tighe, I Belfer, TJ Brennan, S Bruehl… - Pain …, 2017 - academic.oup.com
Objective. With the increasing societal awareness of the prevalence and impact of acute
pain, there is a need to develop an acute pain classification system that both reflects …

Transient receptor potential channels in pain and inflammation: therapeutic opportunities

MA Schumacher - Pain Practice, 2010 - Wiley Online Library
In ancient times, physicians had a limited number of therapies to provide pain relief. Not
surprisingly, plant extracts applied topically often served as the primary analgesic plan. With …

Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures

S Ständer, C Moormann, M Schumacher… - Experimental …, 2004 - Wiley Online Library
The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non‐selective cation
channel that recently has been shown in human keratinocytes in vitro and in vivo. However …

Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence

M Schumacher, S Camp, Y Maulet, M Newton… - Nature, 1986 - nature.com
Acetylcholinesterase, an essential enzyme of the nervous system, rapidly terminates the
action of acetylcholine released into the synapse. Acetylcholinesterase is also found (in …

The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor β3N265M knock-in mouse

AY Zecharia, LE Nelson, TC Gent… - Journal of …, 2009 - Soc Neuroscience
The GABA A receptor has been identified as the single most important target for the
intravenous anesthetic propofol. How effects at this receptor are then translated into a loss of …

[HTML][HTML] Chemotherapy-induced neuropathy in cancer survivors

C Miaskowski, J Mastick, SM Paul, K Topp… - Journal of pain and …, 2017 - Elsevier
Context Evidence suggests that chemotherapy-induced neuropathy (CIN) is a significant
problem for cancer survivors. However, a detailed phenotypic characterization of CIN in …

Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor

Q Xue, B Jong, T Chen… - Journal of …, 2007 - Wiley Online Library
The capsaicin receptor, also known as 'transient receptor potential vanilloid receptor
subtype 1'(TRPV1, VR1), is an ion channel subunit expressed in primary afferent …

[HTML][HTML] Molecular cloning of an N-terminal splice variant of the capsaicin receptor: loss of N-terminal domain suggests functional divergence among capsaicin …

MA Schumacher, I Moff, SP Sudanagunta… - Journal of Biological …, 2000 - ASBMB
Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to
encode an ion channel that is activated by both capsaicin, the pain producing compound in …