Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome

JA Martignetti, AA Aqeel, WA Sewairi, CE Boumah… - Nature …, 2001 - nature.com
The inherited osteolyses or'vanishing bone'syndromes are a group of rare disorders of
unknown etiology characterized by destruction and resorption of affected bones. The …

Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast …

RA Mosig, O Dowling, A DiFeo… - Human molecular …, 2007 - academic.oup.com
The 'vanishing bone'or inherited osteolysis/arthritis syndromes represent a heterogeneous
group of skeletal disorders characterized by mineralization defects of affected bones and …

[PDF][PDF] Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis

O Dowling, A Difeo, MC Ramirez, T Tukel… - The American Journal of …, 2003 - cell.com
Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal
recessive syndromes of unknown etiology characterized by multiple, recurring …

Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b

JM Huston, M Rosas-Ballina, X Xue… - The Journal of …, 2009 - journals.aai.org
The cholinergic anti-inflammatory pathway is a physiological mechanism that inhibits
cytokine production and diminishes tissue injury during inflammation. Recent studies …

Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFκB pathway

B Rochelson, O Dowling, N Schwartz… - Journal of reproductive …, 2007 - Elsevier
Dysfunctional endothelial cell activation and cytokines are implicated in preterm labor, a
condition commonly treated with the tocolytic agent, magnesium sulfate (MgSO4). Based on …

[HTML][HTML] Association of opioids and sedatives with increased risk of in-hospital cardiopulmonary arrest from an administrative database

FJ Overdyk, O Dowling, J Marino, J Qiu, HL Chien… - PloS one, 2016 - journals.plos.org
Background While opioid use confers a known risk for respiratory depression, the
incremental risk of in-hospital cardiopulmonary arrest, respiratory arrest, or cardiopulmonary …

[HTML][HTML] Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity

PK Chatterjee, MM Yeboah, O Dowling, X Xue… - PloS one, 2012 - journals.plos.org
Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop
acute kidney injury (AKI) are at increased risk of death. To date there is no effective …

Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase

PM Cummins, O Dowling, BF O'Connor - … Chromatography: Methods and …, 2011 - Springer
Ion-exchange chromatography (IEC) allows for the separation of ionizable molecules on the
basis of differences in charge properties. Its large sample-handling capacity, broad …

Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection

HBT Tam, O Dowling, X Xue, D Lewis… - American Journal of …, 2011 - Elsevier
OBJECTIVE:: Magnesium sulfate is proposed to have neuroprotective effects in the offspring.
We examined the effects of maternal magnesium sulfate administration on maternal and …

[HTML][HTML] Nicotine inhibits cytokine production by placenta cells via NFκB: potential role in pregnancy-induced hypertension

O Dowling, B Rochelson, K Way, Y Al-Abed… - Molecular Medicine, 2007 - Springer
Abstract Pregnancy-induced hypertension (PIH), also known as preeclampsia, Is one of the
major causes of maternal and fetal death. While the precise cause of PIH is not known …