Objective: To identify the prevalence of monoclonal gammopathy of undetermined
significance (MGUS) in patients with transthyretin (ATTR) amyloidosis. Patients and …

Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These
tumors often pose significant challenges for diagnosis and treatment, and often carry a poor …

Background The COVID-19 pandemic has led to delays in patients seeking care for life-
threatening conditions; however, its impact on treatment patterns for patients with metastatic …

Multiple myeloma (MM) is a clinically and biologically heterogeneous malignancy
characterized by structural and numerical chromosomal abnormalities, mutational and copy …

Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing
and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and …

BACKGROUND Extramedullary multiple myeloma (MM)(EMM) is a rare and aggressive
subentity of MM that can be present at diagnosis or develop anytime during the disease …

Discussion Oxaliplatin is a third-generation platinum derivative that is now considered to be
an integral component of the first-line treatment of colon cancer. 3 Although this drug is more …

The ubiquitin–proteasome system (UPS) plays a central role in cellular protein homeostasis,
through the targeted destruction of regulatory proteins and damaged or misfolded proteins …

Cardiac deposition of misfolded light chains is the leading cause of morbidity and mortality
in patients with immunoglobulin (AL) amyloidosis. Cardiac defibrillators can be used in the …

Background: High dose chemotherapy followed by autologous stem cell transplantation
(ASCT) is the standard of care therapy for patients with newly diagnosed multiple myeloma …