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We would like to thank the authors of the FIRST trial for responding to our paper on ‘Ethical implications of excessive cluster sizes in cluster randomised trials’.1 We are pleased that our paper has generated this interest. The science and methodology of trial design are constantly evolving and will evolve faster, to the future benefit of science, if we can …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; internally peer reviewed.