RT Journal Article SR Electronic T1 Increasing the generalisability of improvement research with an improvement replication programme JF BMJ Quality & Safety JO BMJ Qual Saf FD BMJ Publishing Group Ltd SP i87 OP i91 DO 10.1136/bmjqs.2010.046342 VO 20 IS Suppl 1 A1 John Øvretveit A1 Laura Leviton A1 Gareth Parry YR 2011 UL http://qualitysafety.bmj.com/content/20/Suppl_1/i87.abstract AB If a quality improvement is found effective in one setting, would the same effects be found elsewhere? Could the same change be implemented in another setting? These are just two of the ‘generalisation questions’ which decision-makers face in considering whether to act on reported improvement. In this paper, some of the issues are considered and a programme of research for testing improvements in different settings is proposed to build theory and practical guidance about implementation and results in different settings.