RT Journal Article
SR Electronic
T1 P236 Documentation Of Intellectual Conflicts Of Interests Proved Critical In A Clinical Practice Guideline
JF BMJ Quality & Safety
JO BMJ Qual Saf
FD BMJ Publishing Group Ltd
SP A73
OP A73
DO 10.1136/bmjqs-2013-002293.220
VO 22
IS Suppl 1
A1 E Akl
A1 P El-Hachem
A1 H Abou-Haidar
A1 G Guyatt
YR 2013
UL http://qualitysafety.bmj.com/content/22/Suppl_1/A73.1.abstract
AB Background The American College of Chest Physicians (ACCP) Antithrombotic Guidelines (AT9) addressed both financial and intellectual COI, and restricted panellists from voting on recommendations on which they declared a primary conflict. The extent to which intellectual COI restricted participation beyond financial COI is uncertain. Objective The objective is to describe financial and intellectual COI among AT9 panellists and assess their overlap. Methods The AT9 executive committee developed definitions and categorizations of primary and secondary financial and intellectual COI. panellists reported, for each recommendation, their financial and intellectual COIs. We analysed their declarations. Results Among 102 panellists, the average number of recommendations for which panellist declared COI was: 2.1 (SD 5.7) for secondary financial COI, 1.7 (SD 3.5) for primary financial COI, 5.0 (SD 9.9) for secondary intellectual COI, and 2.5 (SD 5.0) for primary intellectual COI. Of the 102 panellists 37 (36%) declared a primary intellectual but no primary financial COI for at least one recommendation. Among 431 recommendations, the average number of panellists per recommendation who declared COI was: 0.5 (SD 0.8) for secondary financial COI, 0.4 (SD 0.9) for primary financial COI, 1.2 (SD 1.2) for secondary intellectual COI, and 0.6 (SD 1.2) for primary intellectual COI. In 63 recommendations (23%) at least one panellist had a primary intellectual COI but no primary financial COI Conclusion A substantial number of declarations resulted in restrictions based on intellectual COI in the absence of financial COI.