RT Journal Article SR Electronic T1 046 Guideline Development Tool (GDT) – Web-Based Solution for Guideline Developers and Authors of Systematic Reviews JF BMJ Quality & Safety JO BMJ Qual Saf FD BMJ Publishing Group Ltd SP A26 OP A26 DO 10.1136/bmjqs-2013-002293.77 VO 22 IS Suppl 1 A1 J Brozek A1 E Akl A1 Y Falck-Ytter A1 P Kunstman A1 J Meerpohl A1 R Mustafa A1 A Nowak A1 A Oxman A1 N Santesso A1 W Wiercioch A1 H Schünemann YR 2013 UL http://qualitysafety.bmj.com/content/22/Suppl_1/A26.2.abstract AB Background Guideline developers and other health care decision makers benefit from following a structured process of specifying the health care questions they intend to answer and the outcomes of interest, assessing the confidence in the available evidence, gathering information about the values and preferences of the target population, and presentation of their results and decisions to the target users. Many guideline developers use the GRADE Profiler (GRADEpro) software used to conduct this work. Context GRADE’s approach is currently being further defined in the DECIDE (Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence) project. Description of Best Practice The Guideline Development Tool (GDT) is the extension of the GRADE Profiler (GRADEpro) software. The GDT provides an integrated platform-independent web-based solution for health care decision makers offering support for the whole process of making decisions and developing recommendations including question formulation, generation and prioritisation of outcomes, support for teamwork, management of potential conflicts of interest, presentation of results (including the functionality of GRADEpro) and decision support. We tested the software with individual users and in workshops as well as in guideline development processes. Lessons for Guideline Developers, Adaptors, Implementers, and/or Users Following a structured and systematic process, transparency and clarity of presentation facilitates the use of results of systematic reviews and facilitates development, updating and adaptation of evidence-based recommendations and decisions. Storing all information in a uniform, structured, transparent and annotated way also greatly facilitates updating and adaptation of systematic reviews and guidelines.