RT Journal Article SR Electronic T1 Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis JF BMJ Quality & Safety JO BMJ Qual Saf FD BMJ Publishing Group Ltd SP 633 OP 643 DO 10.1136/bmjqs-2015-004450 VO 25 IS 8 A1 Dandoy, Christopher E A1 Hausfeld, Jackie A1 Flesch, Laura A1 Hawkins, Deanna A1 Demmel, Kathy A1 Best, Deanna A1 Osterkamp, Erin A1 Bracke, Tracey A1 Nagarajan, Rajaram A1 Jodele, Sonata A1 Holt, Julie A1 Giaccone, Mary Jo A1 Davies, Stella M A1 Kotagal, Uma A1 Simmons, Jeffrey YR 2016 UL http://qualitysafety.bmj.com/content/25/8/633.abstract AB Background Immunocompromised children are at high risk for central line-associated bloodstream infections (CLABSIs) and its associated morbidity and mortality. Prevention of CLABSIs depends on highly reliable care.Purpose Since the summer of 2013, we saw an increase in patient volume and acuity in our centre. Additionally, CLABSIs rates more than tripled during this period. The purpose of this initiative was to rapidly identify and mitigate potential underlying drivers to the increased CLABSI rate.Methods Through small tests of change, we implemented a standard process for daily hygiene; increased awareness of high-risk patients with CLABSI; improved education/assistance for nurses performing high-risk central venous catheter procedures; and developed a system to improve allocation of resources to de-escalate system stress.Results The CLABSI rate from June 2013 to May 2014 was 2.03 CLABSIs/1000 line days. After implementation of our interventions, we saw a significant decrease in the CLABSI rate to 0.39 CLABSIs/1000 line days (p=0.008). Key processes have become more reliable: 100% of dressing changes are completed with the new two-person standard; daily hygiene adherence has increased from 25% to 70%; 100% of nurses are approached daily by senior nursing for assistance with high-risk procedures; and patients at risk for a CLABSI are identified daily.Conclusions Stress to a complex system caring for high-risk patients can challenge CLABSI rates. Identifying key processes and executing them reliably can stabilise outcomes during times of system stress.