RT Journal Article SR Electronic T1 Incidence, nature and causes of avoidable significant harm in primary care in England: retrospective case note review JF BMJ Quality & Safety JO BMJ Qual Saf FD BMJ Publishing Group Ltd SP bmjqs-2020-011405 DO 10.1136/bmjqs-2020-011405 A1 Anthony J Avery A1 Christina Sheehan A1 Brian Bell A1 Sarah Armstrong A1 Darren M Ashcroft A1 Matthew J Boyd A1 Antony Chuter A1 Alison Cooper A1 Ailsa Donnelly A1 Adrian Edwards A1 Huw Prosser Evans A1 Stuart Hellard A1 Joanne Lymn A1 Rajnikant Mehta A1 Sarah Rodgers A1 Aziz Sheikh A1 Pam Smith A1 Huw Williams A1 Stephen M Campbell A1 Andrew Carson-Stevens YR 2020 UL http://qualitysafety.bmj.com/content/early/2020/11/03/bmjqs-2020-011405.abstract AB Objective To estimate the incidence of avoidable significant harm in primary care in England; describe and classify the associated patient safety incidents and generate suggestions to mitigate risks of ameliorable factors contributing to the incidents.Design Retrospective case note review. Patients with significant health problems were identified and clinical judgements were made on avoidability and severity of harm. Factors contributing to avoidable harm were identified and recorded.Setting Primary care.Participants Thirteen general practitioners (GPs) undertook a retrospective case note review of a sample of 14 407 primary care patients registered with 12 randomly selected general practices from three regions in England (total list size: 92 255 patients).Main outcome measures The incidence of significant harm considered at least ‘probably avoidable’ and the nature of the safety incidents.Results The rate of significant harm considered at least probably avoidable was 35.6 (95% CI 23.3 to 48.0) per 100 000 patient-years (57.9, 95% CI 42.2 to 73.7, per 100 000 based on a sensitivity analysis). Overall, 74 cases of avoidable harm were detected, involving 72 patients. Three types of incident accounted for more than 90% of the problems: problems with diagnosis accounted for 45/74 (60.8%) primary incidents, followed by medication-related problems (n=19, 25.7%) and delayed referrals (n=8, 10.8%). In 59 (79.7%) cases, the significant harm could have been identified sooner (n=48) or prevented (n=11) if the GP had taken actions aligned with evidence-based guidelines.Conclusion There is likely to be a substantial burden of avoidable significant harm attributable to primary care in England with diagnostic error accounting for most harms. Based on the contributory factors we found, improvements could be made through more effective implementation of existing information technology, enhanced team coordination and communication, and greater personal and informational continuity of care.