RT Journal Article SR Electronic T1 Systematic review and meta-analysis of interventions for operating room to intensive care unit handoffs JF BMJ Quality & Safety JO BMJ Qual Saf FD BMJ Publishing Group Ltd SP 513 OP 524 DO 10.1136/bmjqs-2020-012474 VO 30 IS 6 A1 Joanna Abraham A1 Alicia Meng A1 Sanjna Tripathy A1 Michael S Avidan A1 Thomas Kannampallil YR 2021 UL http://qualitysafety.bmj.com/content/30/6/513.abstract AB Objective To conduct a systematic review and meta-analysis to ascertain the impact of operating room (OR) to intensive care unit (ICU) handoff interventions on process-based and clinical outcomes.Method We included all English language, prospective evaluation studies of OR to ICU handoff interventions published as original research articles in peer-reviewed journals. The search was conducted on 11 November 2019 on MEDLINE, CINAHL, EMBASE, Scopus and the Cochrane Central Register of Controlled Trials databases, with no prespecified criteria for the type of comparison or outcome. A meta-analysis of similar outcomes was conducted using a random effects model. Quality was assessed using a modified Downs and Black (D&B) checklist.Results 32 studies were included for review. 31 studies were conducted at a single site and 28 studies used an observational study design with a control. Most studies (n=28) evaluated bundled interventions which comprised information transfer/communication checklists and protocols. Meta-analysis showed that the handoff intervention group had statistically significant improvements in time to analgesia dosing (mean difference (MD)=−42.51 min, 95% CI −60.39 to −24.64), fewer information omissions (MD=−2.22, 95% CI −3.68 to –0.77), fewer technical errors (MD=−2.38, 95% CI −4.10 to –0.66) and greater information sharing scores (MD=30.03%, 95% CI 19.67% to 40.40%). Only 15 of the 32 studies scored above 9 points on the modified D&B checklist, indicating a lack of high-quality studies.Discussion Bundled interventions were commonly used to support OR to ICU handoff standardisation. Although the meta-analysis showed significant improvements for a number of clinical and process outcomes, the statistical and clinical heterogeneity must be accounted for when interpreting these findings. Implications for OR to ICU handoff practice and future research are discussed.Data sharing is not applicable as no data sets were generated and/or analysed for this study. This is a systematic review. No data are available for sharing.