Table 1

 Study design and objectives of the studies included in the systematic review*

Study designNumber of articlesReferencesNumber of articles in each study design category intending to test utility of SPCReferences
*The study designs are reported in order of frequency.
Case study2816, 17, 19–21, 24, 26, 29, 33, 34, 36, 39, 41, 44–49, 53, 55, 57, 58, 61, 63–65, 671616, 17, 20, 24, 26, 36, 41, 44, 47, 48, 57, 61, 63–65, 67
Tutorial with illustrative case study2315, 18, 22, 23, 25, 27, 30, 31, 35, 37, 38, 40, 42, 50–52, 54, 59, 62, 66, 69–71322, 25, 30
Observational study of change in clinical procedure(s) using historical controls243, 680
Controlled before-and-after intervention studies228, 56156
Patient case reports232, 60232, 60