	Model	Rate (%)		Difference (95% CI)		p Value
Phase of the process
Prescription	Manual	8.44		3.12% (1.3 to 5)		0.0017
Prescription	Automated	5.32		3.12% (1.3 to 5)		0.0017
Transcription	Manual	18.3		4.6% (1.9 to 7.3)		0.0009
Transcription	Automated	13.7		4.6% (1.9 to 7.3)		0.0009
Administration	Manual	14.48		9.5% (6.3 to 12.7)		0.00001
Administration	Automated	4.98		9.5% (6.3 to 12.7)		0.00001
Global rate	Manual	14.48		5.62% (3.3 to 6.2)		0.00001
Global rate	Automated	8.86		5.62% (3.3 to 6.2)		0.00001
Categorizing medication errors
Without error	Manual		84.44		−10.09 (−13.4 to −6.7)	0.0000
Without error	Automated		94.53		−10.09 (−13.4 to −6.7)	0.0000
A. Have the capacity to cause error	Manual		0.107		0.107 (−0.3 to +0.5)	0.68
A. Have the capacity to cause error	Automated		0		0.107 (−0.3 to +0.5)	0.68
B. Error didn’t reach patient	Manual		0.107		−0.123 (−0.8 to +0.6)	0.85
B. Error didn’t reach patient	Automated		0.23		−0.123 (−0.8 to +0.6)	0.85
C. Error reached patient but didn’t cause harm	Manual		8.69		4.89 (2.1 to 7.6)	0.0018
C. Error reached patient but didn’t cause harm	Automated		3.8		4.89 (2.1 to 7.6)	0.0018
D. Error reached patient and required monitoring	Manual		3.86		3.15 (1.5 to 4.8)	0.0024
D. Error reached patient and required monitoring	Automated		0.71		3.15 (1.5 to 4.8)	0.0024
E. Error with temporary harm	Manual		1.502		1.27 (0.2 to 2.3)	0.05
E. Error with temporary harm	Automated		0.23		1.27 (0.2 to 2.3)	0.05
F. Error with temporary harm that required hospitalisation	Manual		0.32		0.32 (−0.2 to +0.9)	0.58
F. Error with temporary harm that required hospitalisation	Automated		0		0.32 (−0.2 to +0.9)	0.58
Not classified	Manual		0.96		0.49 (−0.6 to +1.6)	0.54
Not classified	Automated		0.47		0.49 (−0.6 to +1.6)	0.54