| Antiepileptic (toxicity or subtherapeutic) | 1 |
| Digoxin (toxicity or subtherapeutic) | 2 |
| Poorly controlled angina on submaximal therapy | – |
| Thrombotic event in patient not prescribed aspirin (where aspirin is indicated) | 1 |
| Diabetes poorly controlled with insulin or sulphonylureas | 3 |
| Aspirin/non-steroidal anti-inflammatory drug (NSAID)-induced gastrointestinal bleed or renal failure | 6 |
| Exacerbation of asthma in patients poorly adherent to preventer therapy | 2 |
| Dehydration or electrolyte imbalance with diuretics | 2 |
| Adverse reaction to initiation or cessation of β-blocker | 1 |
| Warfarin with a bleeding event and a raised international normalised ratio (INR) or a thrombotic event and a subtherapeutic INR on warfarin | 3 |