| Antipsychotic | Primary psychotic disorder/persistent psychotic symptoms | Non-psychotic indication |
| Mood stabilizer/antiepileptic drug | Current/recent or history of severe manic episode | Indication unclear or agitation, impulsiveness and benefit unclear |
| Antidepressant | Current/recent or history of severe major depressive episode | Depressed mood limited to brief period of resolving psychosis; transient and secondary to adversity, demoralization |
| Benzodiazepine | For most indications—temporary use (e.g. alcohol withdrawal) | Insomnia/anxiety secondary disorder targeted by other medication therapy (taper if use continuous/longstanding) |
| Stimulants | Well-established diagnosis of attention-deficit hyperactivity disorder or narcolepsy | Indication unclear or not well established, equivocal response |