| Trigger type | Site 1 | Site 2 | Site 3 | Site 4 | Site 5 | Site 6 | All sites | |||||||
| Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | Triggers | ADEs (PPV) | |
| 1. Medication stop | 91 | 14 (15.4%) | 92 | 9 (9.8%) | 83 | 28 (33.7%) | 106 | 13 (12.3%) | 133 | 45 (33.8%) | 85 | 46 (54.1%) | 590 | 155 (26.3%) |
| 2. Hospitalisation | 25 | 7 (28.0%) | 12 | 2 (16.7%) | 6 | 1 (16.7%) | 14 | 3 (21.4%) | 23 | 4 (17.4%) | 21 | 5 (23.8%) | 101 | 22 (21.8%) |
| 3. Emergency-room visit | 26 | 5 (19.2%) | 22 | 1 (4.5%) | 9 | 2 (22.2%) | 6 | 1 (16.7%) | 14 | 3 (21.4%) | 17 | 2 (11.8%) | 94 | 14 (14.9%) |
| 4. INR>5 | 1 | 1 (100%) | 0 | – | 4 | 4 (100%) | 1 | 1 (100%) | 2 | 2 (100%) | 0 | – | 8 | 8 (100%) |
| 5. TSH<0.03 on thyroxine | 2 | 2 (100%) | 1 | 1 (100%) | 0 | – | 1 | 1 (100%) | 3 | 3 (100%) | 3 | 2 (66.7%) | 10 | 9 (90%) |
| 6. Creat>2.5 | 5 | 0 (0%) | 2 | 0 (0%) | 3 | 2 (66.7%) | 1 | 0 (0%) | 0 | – | 4 | 0 (0%) | 15 | 2 (13.3%) |
| 7. BUN>60 | 1 | 0 (0%) | 1 | 0 (0%) | 6 | 1 (16.7%) | 2 | 0 (0% | 0 | – | 5 | 0 (0%) | 15 | 1 (6.7%) |
| 8. ALT>84 | 1 | 0 (0%) | 7 | 2 (28.6%) | 0 | – | 0 | – | 3 | 3 (100%) | 2 | 0 (0%) | 13 | 5 (38.5%) |
| 9. AST>80 | 1 | 0 (0%) | 12 | 1 (8.3%) | 0 | – | 0 | – | 2 | 2 (100%) | 0 | – | 15 | 3 (20%) |
| Subtotal of above 9 triggers | 153 | 29 (19.0%) | 149 | 16 (10.7%) | 111 | 38 (34.2%) | 131 | 19 (14.5%) | 180 | 62 (34.4%) | 137 | 55 (40.1%) | 861 | 219 (25.4%) |
| Subtotal of rest of triggers | 3 | 1 (33.3%) | 17 | 1 (5.9%) | 10 | 4 (40%) | 3 | 0 (0%) | 8 | 4 (50.0%) | 6 | 3 (50.0%) | 47 | 13 (27.7%) |
| Total of all triggers | 156 | 30 (19.2%) | 166 | 17 (10.2%) | 121 | 42 (34.7%) | 134 | 19 (14.8%) | 188 | 66 (35.1%) | 143 | 58 (40.6%) | 908 | 232 (25.5%) |
| Sensitivity of the top 9 triggers (% of ADEs detected by these) | 98.1% | 96.7% | 89.8% | 94.1% | 91.7% | 90.5% | 97.8% | 100% | 95.7% | 93.9% | 95.8% | 94.8% | 94.8% | 94.4% |
ADE, adverse drug event; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; INR, international normalized ratio; PPV, positive predictive value; TSH, thyroid-stimulating hormone.