| Five domains of failure | Areas of potential solutions |
| Failure to learn from adverse events | Research into causes, universal reporting and learning systems |
| Failure of international translation | Common taxonomy for reporting and learning |
| Failure to achieve compliance with safety guidance | Evidence-based solutions, power and levers to mandate change |
| Failure of investigations and enquiries | Patient safety bodies cooperating nationally and internationally |
| Failure of solutions | Actionable alerts, protocols and forcing functions |