Definition of specific maximum recommended therapeutic dose (MRTD) values
| Type of MRTD value | Characteristic of MRTD value | Number of extracted values for the study |
| MRTDROA | Standard MRTD value referring to a drug with a specific route of administration and dosage form | 170 |
| MRTDAge | Lower MRTD value applying to elderly patients (patient's age is automatically extracted from the patient's electronic chart) | 17 |
| MRTDIndication | Lower MRTD value applying to specific indications (encoded ICD-10 codes are automatically extracted from the patient's electronic chart) | 39 |
| MRTDLiver | Lower MRTD value applying to patients with impaired liver function (if relevant, the physician was asked to specify the patient's liver function) | 13 |
| MRTDDDI_down | Lower MRTD value due to interacting comedication increasing drug exposure (concurrently prescribed drugs are automatically extracted from the medication regimen) | 9 |
| MRTDDDI_up | Higher MRTD value due to interacting comedication reducing drug exposure (concurrently prescribed drugs are automatically extracted from the medication regimen) | 4 |
| MRTDTimepoint | Higher MRTD value applying to substances given at higher dosages at the beginning of therapy (if relevant, the physician was asked to specify whether he intended to administer a loading dose) | 25 |
| MRTDKidney | Higher MRTD value applying to substances that require dosage increase in case of renal impairment (laboratory values determining renal function were automatically extracted from the patient's electronic chart) | 3 |
ICD-10, International Statistical Classification of Diseases and Related Health Problems - 10th Revision.