Table 3

Univariate and multivariate analysis of predictors for physicians' adherence to the 559 overdose alerts issued in the 45-day intervention phase.

p Valuep Valueβ
Patient age0.0010.0030.023
Number of drugs<0.0010.017−0.057
Prescribed compound<0.001<0.001
Analgesics and non-steroidal anti-inflammatory drugs0.0022.481
Cardiovascular drugsReference
Immunomodulating and antineoplastic drugs0.0022.541
Psychotropic drugs0.0031.463
Reason for the alert<0.001<0.001
Prescribed daily dose > iMRTD valueReference
Loading dose not specified0.5660.229
Plasma concentration in excess of therapeutic levels<0.001−3.35
No dosage adjustment to renal function0.980.005
Duplicate prescription<0.0012.05
  • Table includes all predictors with statistically significant impact on alert adherence.

  • iMRTD, MRTDfinal was individualised to renal function.