Table 3

Univariate and multivariate analysis of predictors for physicians' adherence to the 559 overdose alerts issued in the 45-day intervention phase.

Criteria	Specification	Univariate	Multivariate
Criteria	Specification	p Value	p Value	β
Patient age		0.001	0.003	0.023
Number of drugs		<0.001	0.017	−0.057
Prescribed compound		<0.001	<0.001
	Analgesics and non-steroidal anti-inflammatory drugs		0.002	2.481
	Anti-infectives		0.623	−0.225
	Cardiovascular drugs		Reference
	Hormones		0.659	−0.204
	Immunomodulating and antineoplastic drugs		0.002	2.541
	Psychotropic drugs		0.003	1.463
	Miscellaneous		0.015	1.15
Reason for the alert		<0.001	<0.001
	Prescribed daily dose > iMRTD value		Reference
	Loading dose not specified		0.566	0.229
	Plasma concentration in excess of therapeutic levels		<0.001	−3.35
	No dosage adjustment to renal function		0.98	0.005
	Duplicate prescription		<0.001	2.05

Table includes all predictors with statistically significant impact on alert adherence.
iMRTD, MRTD_final was individualised to renal function.