The comparison of epidemiology of adverse drug events among paediatric settings
| Study | JADE study | Agarwal S18 | Takata GS9 | Kunac DL10 | Holdsworth MT8 | Kaushal R7 |
|---|---|---|---|---|---|---|
| Country and studied year | Japan, 2012 | U.S., 2005 | U.S., 2003 | New Zealand, 2002 | U.S., 2000 | U.S., 2000 |
| Patients and setting | All patients admitted at two teaching hospitals | Randomly selected patients from 15 hospitals | 5 hospitals participating in the California Paediatric Patient Safety Initiative | All patients admitted at a university-affiliated urban general hospital | All patient admitted at a large metropolitan tertiary care centre | All patient admitted at 2 academic institutions |
| Wards | Paediatric medical/surgical wards, two NICUs and a PICU* | 15 PICUs | Paediatric wards, PICUs, and NICUs | A paediatric ward, a NICU and a postnatal ward | A paediatric ward and a PICU | 9 ward including paediatric medical/ surgical wards, NICUs, PICUs, and short-stay medical ward |
| Number of admissions | 1189 | 734 | Not available | 520 | 1197 | 1120 |
| Data acquisition method | Reviewers, historical cohort study | Cross sectional retrospective review with trigger methods | Trigger methods | Review by the principal investigator, prospective cohort study | A reviewer, Prospective cohort study | Reviewers, Prospective cohort study |
| Incidence of ADEs (ADEs/1000 patient days) | 37.8 | 49 | 22.3 | 22.1 | 7.5 | 6.6 |
| Rate of ADEs (ADEs/100 admissions) | 40.4 | 34.9 | 11.2 | 12.9 | 6 | 2.3 |
| Rate of patients who had at least one ADE | 20% | Not available | 9% | Not available | Not available | Not available |
*Studied the patients admitted at the ICU, the emergent care unit and the general adult ward when paediatric patients (≤15 years old) were admitted.
ADEs, adverse drug events; JADE, Japan Adverse Drug Events; NICU, neonatal intensive care unit; PICU, paediatric intensive care unit;.