Table 1

Barriers to timely antibiotic delivery and associated interventions

Findings from failure mode effects analysisLOR 2 interventionsNumber of PDSA cycles
Pre-arrival interventions
location: ED
PDSA cycle timing:
July 2010 to June 2011
Referral information relayed to one attendingStandardised referral made to ED physician, charge RN and clerical staff4
Variable information collected and delivered at time of referralEMR-based referral checklist with pre-populated patient specific information with a smart phrase and link6
Intermittent communication amongst ED staffPre-arrival team huddle5
Orders completed after patient's ED evaluationStandardised order set completed at time of referral (labs and antibiotics)3
Post-arrival interventions
location: ED
PDSA cycle timing:
July 2011 to November 2011
Variable awareness of patient arrival to EDStandardised arrival process3
Lack of a standard team approach to patient evaluation and antibiotic administrationStandardised room-to-antibiotic administration process3
Clinical-specific interventions
location: clinic
PDSA cycle timing:
March 2011 to July 2011
Variable awareness of the amount of time F&I patients had been in the clinic prior to antibiotic administrationUse of a 60 min countdown timer for all F&I patients3
Unreliable identification of F&I patients prior to arrival in the clinicStandardised process of identification of F&I patients prior to arrival in the clinic2
Delayed antibiotic administration secondary to delayed registrationStandardised prompt registration process for F&I patients2
Sustaining of interventions
location: ED/clinic
timing: December 2011 to January 2015
Variation in education modalities for vascular access and F&I processStandardised education module for all ED and clinic staff including interval refresher courses3
Variable awareness of process amongst staff and leadershipPosting of updated run-charts for staff and monthly review of F&I results on ED/CBDI dashboards2
Variable understanding of FailuresRapid analysis of all failures1
Delay in port access secondary to delayed application of EMLA cream on the port siteStandardised process to review EMLA cream availability at home upon hospital discharge and during clinic visits1
Enhancing sustainability
location: ED
timing: 9/14–1/15
Delayed port accessImplementation of the rapid response team, which included a vascular access team member2
  • CBDI, Cancer and Blood Disease Institute; ED, emergency department; EMLA, eutectic mixture of local anaesthetics lidocaine/prilocaine; EMR, electronic medical record; F&I, febrile immunocompromised; LOR, level of reliability; PDSA, Plan-Do-Study-Act.