Table 1

Effectiveness of the central line bundle to reduce central line-associated blood stream infections, in various subgroups

SubgroupHeterogeneity (%)Effectiveness RR (95% CI)Test of difference
PopulationAdult950.45 (0.33 to 0.60)χ²=8.98
p=0.01
Paediatric620.56 (0.48 to 0.64)
Both860.37 (0.29 to 0.47)
SettingICU920.42 (0.36 to 0.49)χ²=5.97
p=0.05
Non-ICU270.56 (0.47 to 0.68)
Entire hospital (ICU and non-ICU)00.46 (0.38 to 0.55)
Study designStepped wedgen.a.*0.74 (0.64 to 0.85)χ²=31.06
p<0.001
Time series830.50 (0.36 to 0.69)
Controlled before-aftern.a.0.35 (0.22 to 0.56)
Uncontrolled before-after900.43 (0.36 to 0.50)
 Controlled studies and time series820.52 (0.42 to 0.64)χ²=2.12
p=0.15
Uncontrolled before-after900.43 (0.36 to 0.50)
Risk of bias4+ domains low risk, no high risk00.48 (0.34 to 0.68)χ²=0.18
p=0.67
Other studies910.44 (0.39 to 0.51)
  • *Heterogeneity could not be calculated given too few studies.

  • ICU, intensive care unit.