Unadjusted and adjusted effect of the intervention on self-reported non-adherence measured using the Diagnostic Adherence to Medication Scale at 4 week follow-up and 6 month follow-up
| χ2 | Logistic Regression | Generalised estimating equations analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Proportion <90% adherent | Unadjusted | Adjusted* | Unadjusted | |||||||
| n | Intervention | Control | p value | n | OR (95% CI, p value) | n | OR (95% CI, p value) | n | OR (95% CI, p value) | |
| Four-week follow-up | ||||||||||
| Intention to treat (ITT) | 677 | 39/340 (11.5) | 68/337 (20.2) | † | 677 | 1.93 (1.22 to 3.05, 0.005) | 677 | 2.20 (1.33 to 3.65, 0.002) | ||
| Available cases‡ | 564 | 19/270 (7.0) | 50/294 (17.0) | 0.000 | 564 | 2.71 (1.55 to 4.72, 0.000) | 556 | 3.53 (1.87 to 6.67, 0.000) | ||
| Complete cases§ | 494 | 17/244 (7.0) | 39/250 (15.6) | 0.004 | 494 | 2.47 (1.35 to 4.50, 0.003) | 494 | 3.43 (1.72 to 6.84, 0.000) | ||
| 6 month follow-up | ||||||||||
| ITT | 677 | 36/340 (10.6) | 66/337 (19.6) | † | 677 | 2.04 (1.23 to 3.40, 0.006) | 677 | 2.24 (1.29 to 3.88, 0.004) | 677 | 1.54 (1.11 to 2.15, 0.010) |
| Available cases | 541 | 16/270 (5.9) | 41/271 (15.1) | 0.001 | 541 | 2.83 (1.55 to 5.18, 0.001) | 532 | 3.40 (1.75 to 6.61, 0.000) | 673 | 1.82 (1.26 to 2.61, 0.001) |
| Complete cases | 494 | 14/244 (5.7) | 35/250 (14.0) | 0.003 | 494 | 2.67 (1.40 to 5.11, 0.003) | 494 | 3.48 (1.69 to 7.15, 0.001) | 494 | 1.69 (1.10 to 2.61, 0.017) |
*Logistic regression adjusted for age, gender, therapeutic group, number of prescription items, reminder service, baseline adherence
†No p values are provided for ITT analyses. SPSS does not support doing a χ2 test on imputed data sets.
‡Available case analysis included all available data at each time point.
§Complete case analysis included only those who had questionnaire data available at all three data collection points.