Table 1

Components of the six different clinical profiles by risk level

Clinical profile	Information volunteered by ‘patient’ or available onscreen			Information only available if participant GPs asked		Positive predictive value (PPV) of lung cancer (%)	Other relevant information
Clinical profile	Age range	Smoking status	Symptom 1	Symptom 2	Duration	Positive predictive value (PPV) of lung cancer (%)	Other relevant information
Low risk: Expected action=no active investigation (safety netting appropriate)
1	Younger (late 50s)	Non-smoker	Breathlessness	Fatigue	1–2 weeks	0.40	Patient has swollen ankles, possibly due to heart failure
2	Younger (late 50s)	Smoker	Chest pain	Cough	1–2 weeks	1.10
Medium risk: Expected action=either investigation (eg, order chest X-ray) or safety netting
3	Older (late 70s)	Smoker	Chest pain	Cough	Uncertain (∼3 weeks)	1.70
4	Older (late 70s)	Non-smoker	Cough	Appetite loss	Uncertain (∼3 weeks)	2.50
High risk: Expected action=lung cancer investigation
5	Younger (late 50s)	Smoker	Breathlessness	Fatigue	>5 weeks	3–4	Chronic obstructive pulmonary disease present
6	Older (late 70s)	Smoker	Chest pain	Weight loss	>5 weeks	14