Table 2

Factors associated with failure to receive recommended chemotherapy by disease site

Breast cancerColon cancerLung cancer
Rate, %OR (95% CI)P valueRate, %OR (95% CI)P valueRate, %OR (95% CI)P value
Overall3.56.610.7
General characteristics
Sex
Male---------6.51.0Ref11.01.0Ref
Female---------6.60.98 (0.93 to 1.03)0.45010.30.98 (0.85 to 1.12)0.732
Age
<55 years2.51.0Ref3.41.0Ref7.41.0Ref
55–69 years4.51.90 (1.76 to 2.04)<0.0015.51.66 (1.53 to 1.81)<0.0018.81.27 (0.98 to 1.64)0.071
70+ years---------10.53.56 (3.23 to 3.92)<0.00114.12.26 (1.75 to 2.93)<0.001
Race/ethnicity
Non-Hispanic white3.41.0Ref6.31.0Ref10.61.0Ref
Non-Hispanic black4.11.26 (1.14 to 1.40)<0.0018.11.38 (1.26 to 1.51)<0.00110.31.04 (0.81 to 1.34)0.740
Hispanic2.70.80 (0.66 to 0.98)0.0274.80.72 (0.62 to 0.84)<0.00111.31.07 (0.64 to 1.81)0.794
Asian3.10.92 (0.73 to 1.15)0.4397.31.12 (0.94 to 1.32)0.20413.11.43 (0.97 to 2.12)0.075
Other5.71.68 (1.30 to 2.18)<0.0017.11.15 (0.93 to 1.42)0.20610.11.02 (0.59 to 1.77)0.930
Median household income
$63 000+3.11.0Ref5.51.0Ref9.91.0Ref
$48 000-$62 9993.41.07 (0.95 to 1.21)0.2346.51.11 (1.02 to 1.20)0.01910.71.01 (0.80 to 1.28)0.917
$38 000-$47 9993.71.17 (1.02 to 1.35)0.0287.01.21 (1.10 to 1.34)<0.00111.01.04 (0.81 to 1.34)0.760
<$38 0004.31.36 (1.15 to 1.61)<0.0017.81.30 (1.16 to 1.46)<0.00111.31.10 (0.81 to 1.50)0.551
Local high school diploma
<7%3.11.0Ref5.61.0Ref10.21.0Ref
7%–13%3.51.05 (0.93 to 1.18)0.4516.51.07 (0.99 to 1.16)0.10710.31.05 (0.85 to 1.3)0.662
13%–21%3.60.98 (0.84 to 1.14)0.8186.81.06 (0.96 to 1.18)0.27311.11.09 (0.85 to 1.4)0.509
21% and up3.90.98 (0.81 to 1.18)0.8317.41.13 (1.00 to 1.28)0.05911.31.09 (0.8 to 1.48)0.598
Insurance status
Insured/Medicare4.01.0Ref7.71.0Ref11.61.0Ref
Uninsured/Medicaid3.41.30 (1.16 to 1.45)<0.0016.41.62 (1.46 to 1.79)<0.00110.61.40 (1.08 to 1.82)0.012
Other/unknown3.91.21 (0.94 to 1.55)0.1317.61.41 (1.07 to 1.86)0.0159.00.87 (0.45 to 1.69)0.679
Charlson-Deyo Score
03.41.0Ref6.11.0Ref10.41.0Ref
13.80.97 (0.88 to 1.08)0.6317.41.06 (0.99 to 1.12)0.09011.01.01 (0.87 to 1.18)0.851
2+5.21.25 (1.00 to 1.56)0.0519.21.26 (1.13 to 1.41)<0.00110.60.92 (0.72 to 1.16)0.472
Year of treatment
2006–20084.11.62 (1.41 to 1.85)<0.0015.50.74 (0.66 to 0.82)<0.001---------
2009–20113.41.26 (1.12 to 1.42)<0.0017.00.94 (0.85 to 1.04)0.214---------
2012–20133.61.28 (1.12 to 1.45)<0.0016.90.89 (0.80 to 0.98)0.024---------
2014–20152.91.0Ref7.61.0Ref---------
Hospital characteristics
Hospital type
Academic3.01.0Ref6.41.0Ref10.11.0Ref
Non-academic3.81.26 (1.13 to 1.41)<0.0016.61.05 (0.93 to 1.18)0.46311.11.06 (0.89 to 1.26)0.519
Hospital region
New England3.31.13 (0.88 to 1.46)0.3286.21.22 (1.01 to 1.47)0.03810.80.98 (0.71 to 1.36)0.907
Middle Atlantic3.31.12 (0.93 to 1.35)0.2366.41.19 (1.01 to 1.40)0.0398.00.67 (0.49 to 0.91)0.012
South Atlantic3.41.0Ref5.81.0Ref11.61.0Ref
East North Central3.71.18 (1.02 to 1.36)0.0267.41.32 (1.17 to 1.50)<0.00110.20.91 (0.71 to 1.18)0.495
East South Central3.81.09 (0.89 to 1.33)0.3976.41.04 (0.84 to 1.30)0.6959.60.79 (0.60 to 1.04)0.097
West North Central3.00.93 (0.77 to 1.13)0.4747.1%1.30 (1.11 to 1.52)0.00113.61.20 (0.89 to 1.63)0.234
West South Central3.20.98 (0.82 to 1.17)0.8075.50.96 (0.81 to 1.15)0.68412.01.06 (0.75 to 1.50)0.741
Mountain4.21.37 (1.09 to 1.73)0.0077.91.56 (1.27 to 1.91)<0.00112.71.15 (0.82 to 1.62)0.427
Pacific4.11.37 (1.16 to 1.63)<0.0017.41.47 (1.29 to 1.67)<0.00110.90.89 (0.66 to 1.21)0.461
Patient travel
<5 miles3.61.0Ref6.81.0Ref9.81.0Ref
5–9.9 miles3.51.02 (0.91 to 1.14)0.7596.30.99 (0.91 to 1.06)0.6989.91.04 (0.83 to 1.30)0.753
10–19.9 miles3.41.04 (0.92 to 1.17)0.5356.21.05 (0.97 to 1.14)0.22811.11.20 (0.97 to 1.49)0.096
20+ miles3.61.07 (0.96 to 1.20)0.2346.81.04 (0.96 to 1.14)0.34411.41.18 (0.97 to 1.44)0.097
Tumour characteristics
Pathologic T-stage
Tis/T13.41.0Ref5.91.0Ref9.91.0Ref
T23.91.02 (0.91 to 1.14)0.7597.01.14 (0.96 to 1.36)0.12111.91.17 (0.98 to 1.38)0.077
T3/T43.41.04 (0.92 to 1.17)0.5356.91.13 (0.98 to 1.32)0.1019.90.96 (0.78 to 1.19)0.736
Tx0.44.30.80 (0.67 to 0.95)0.0126.80.66 (0.39 to 1.09)0.106
Pathological N-stage
N04.22.60 (2.23 to 3.04)<0.001------------------
N12.51.42 (1.20 to 1.68)<0.0017.11.27 (1.19 to 1.34)<0.00112.51.56 (1.33 to 1.83)<0.001
N2+1.91.0Ref5.61.0Ref8.41.0Ref
Other N+------------------8.71.31 (0.91 to 1.87)0.142