Table 1

Inclusion and exclusion criteria of the OPERAM trial and the embedded mixed-methods study (created by the authors)

OPERAM trial	Mixed-methods study embedded in OPERAM
Inclusion criteria: 70 years or older. Multimorbidity (≥3 chronic conditions ≥6 months). Polypharmacy (≥5 chronic medications). Exclusion criteria: Direct admission to palliative care. Report of a structured medication review within the last 2 months. The OPERAM intervention consisted of the Structured Method to Reduce Inappropriate Prescribing including structured history taking of medication use, a CDSS-assisted medication review based on the STOPP/START V.2 criteria, discussion of medication optimisation recommendations with the attending physician and the patient and generation of a discharge report with recommendations for the GP. The control arm received usual care.	Inclusion criteria: ≥1 change in chronic medication proposed during hospitalisation, for example, the addition, discontinuation or modification of a medicine. The medication change could be a result of the OPERAM intervention or usual care. Informative patients willing to share their experience. Exclusion criteria: Inability to provide informed consent. Patients with confusion, dementia or severe cognitive impairment. Unacceptable living distance from the clinical sites (for pragmatic reasons).

OPERAM trial

Mixed-methods study embedded in OPERAM

Inclusion criteria:

70 years or older.
Multimorbidity (≥3 chronic conditions ≥6 months).
Polypharmacy (≥5 chronic medications).

Exclusion criteria:

Direct admission to palliative care.
Report of a structured medication review within the last 2 months.

The OPERAM intervention consisted of the Structured Method to Reduce Inappropriate Prescribing including structured history taking of medication use, a CDSS-assisted medication review based on the STOPP/START V.2 criteria, discussion of medication optimisation recommendations with the attending physician and the patient and generation of a discharge report with recommendations for the GP.
The control arm received usual care.

Inclusion criteria:

≥1 change in chronic medication proposed during hospitalisation, for example, the addition, discontinuation or modification of a medicine. The medication change could be a result of the OPERAM intervention or usual care.
Informative patients willing to share their experience.

Exclusion criteria:

Inability to provide informed consent.
Patients with confusion, dementia or severe cognitive impairment.
Unacceptable living distance from the clinical sites (for pragmatic reasons).

CDSS, Clinical Decision Support System; GP, general practitioner; START, Screening Tool to Alert to Right Treatment; STOPP, Screening Tool of Older People’s Prescriptions.