Table 4

Pooled estimates from meta-analyses

	General care population		General care population		Intensive care population		P value between populations (GTT/TT)
	HMPS methodology		GTT/TT methodology
	N of samples	Pooled estimates (95% PI)	N of samples	Pooled estimates (95% PI)	N of samples	Pooled estimates (95% PI)
Primary outcome
Percentage of admissions with ≥1 AEs	9	3.9 (0.3–33.7)	13	17.7 (3.8–53.8)	10	47.3 (6.9–91.6)	0.0003
Secondary outcomes
AEs per 100 admissions	–	–	13	24.8 (4.2–145.2)	11	103.6 (15.3–699.7)	< 0.0001
AEs per 1000 patient days	–	–	12	48.3 (5.9–393.1)	10	126.2 (6.4–2495.1)	0.0418
Percentage of preventable AEs	5	53.2 (10.4–91.8)	4	58.6 (7.4–96.2)	7	67.4 (4.5–98.9)	0.5355
Percentage of admissions with preventable AEs	4	2.3 (0.0–59.3)	3	7.3 (0.0–100.0)	5	25.0 (2.5–81.3)	0.0467

AEs, adverse events; GTT, Global Trigger Tool; HMPS, Harvard Medical Practice Study; PI, prediction interval; TT, Trigger Tool.