Table 2

Acceptance and refusals of 168 patients assessed with the hydroxyurea (HU) barrier questionnaire

Patients who accepted HU and barriers reportedPatients who declined HU and reasons for declining
Patients who acceptedNumber (%)Reasons for refusalNumber (%)
Accepted and had no barriers91/136 (67)Don’t like to take medication
‘My SCD is not bad’
Fear of side effects
Fear of taking chemotherapy
Reason unknown
Don’t understand about HU
6 (18.8)
5 (15.6)
5 (15.6)
5 (15.6)
10 (31.2)
1 (3.1)
Accepted but had barriers45/136 (33)
Forces to take it11 (24.4)
Forgets to take it8 (17.8)
Perceived lack of effect8 (17.8)
Other7 (15.5)
Taste2 (4.4)
Nausea2 (4.4)
Can’t afford1 (2.2)
Did not state problem6 (13.3)
Total patients who accepted HU 136 (81) Total patients who
declined HU
32 (19)
  • Patients were able to select more than one barrier to acceptance and/or reason for refusal.

  • SCD, sickle cell disease.