Original article: cardiovascularAssociation of bacterial infection and red blood cell transfusion after coronary artery bypass surgery
Section snippets
Patient selection
During a 7-month period, 605 adult patients underwent primary isolated CABG at Maine Medical Center, a tertiary care, university-affiliated teaching hospital. We excluded patients who received antimicrobial therapy during the 72 hours prior to surgery (n = 60), transfusion of any blood products during the week preceding surgery (n = 8), and those who expired within 48 hours of CABG (n = 4). The remaining 533 patients were enrolled in the study and followed postoperatively with daily reviews of
Results
Seventy-five of 533 patients developed a bacterial infection during the study (14.1%). Of these, 46 (61.3%) developed bacterial infection prior to hospital discharge and 29 (38.7%) developed infection after discharge. Nine patients died; 5 of 75 (6.7%) with bacterial infection died, while 4 of 458 (0.9%) of non-infected patients died (p < 0.001). The endpoint of the study for the remaining 485 patients was their 1-month post-discharge office visit. The questionnaire response rate for these
Comment
In this prospective study, 533 patients having isolated CABG surgery were studied and 75 (14.1%) developed a bacterial infection. The sites of the infections were 32.4% respiratory, 41.9% superficial SSI, 8.1% deep SSI (all sternal), and 17.6% at other sites. After adjustment for patient and treatment characteristics, surgical times, and the transfusion of other substances, the rates of postoperative bacterial infection remained strongly associated with the number of units of RBC transfused.
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