Prevalence, clinical characteristics, quality of life, and prognosis of patients with congestive heart failure and isolated left ventricular diastolic dysfunction
Section snippets
Patients
The patient cohort included patients < 85 years of age and with adequate 2-dimensional echocardiographic study who were discharged with a primary diagnosis of HF from the 4 departments of internal medicine or from the department of cardiology of the S Maria della Misericordia, Udine, Italy, a 790-bed tertiary hospital that is part of an academic medical center, between April 1999 and January 2000. Demographic information about the catchment area of our hospital are available from published
Study population
A total of 145 patients (median age 75 years; 50% men) met the inclusion criteria. Among these, 12 patients were excluded because of inadequate Doppler echocardiographic studies in 9 (5%) and significant valvular heart disease other than mitral regurgitation as a result of mitral anulus dilation in 3 (2%). Finally, 2 patients did not show any evidence of systolic or diastolic LV dysfunction. Among the remaining 131 study patients, there were 29 patients (22%) with isolated LV diastolic
Discussion
This study was performed in a well-defined cohort of patients consecutively discharged from our hospital with a confirmed diagnosis of HF, and used standardized echocardiographic criteria for diagnosing isolated LV diastolic dysfunction. Our findings can be summarized as follows: (1) prevalence of isolated LV diastolic dysfunction in patients hospitalized with HF encompass 22% of patients in sinus rhythm and without significant valvulopathy; (2) patients given the diagnosis of isolated LV
Acknowledgements
We thank Pasquale Gianfagna, MD, and Rosanna Ciani, MD, for their help in performing a number of echocardiograms. We also thank the internists of our hospital who referred their patients to our echocardiographic laboratory. Finally, we are indebted to Dario Gregori, PhD, for his expert statistical analysis of data.
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