Summary
In the current climate of cost containment a nd qualit y control, nosocomial infection is a worrisome adverse evcnt in hospital care. Hospitaliscd paticnts rcquire care for increasingly scvere illncsses. and are therefore morc susceptible to infection. especially by opponunistic micro–organisms. It is thus nccessary to accurately assess and adjust for the severity of the underlying illness in studies of risk factors involved in nosocomial infections.
The appearance of new diagnostic and therapeutic tcch niques providcs novcl opponunities for infection control and rcpresents a constant challenge to hospital systems. The continuous selection of resistant flora, together with the identification of new pathogens, call s for a reconsiderat ion of hospital policies regarding the dispensation of antibiotics.
Epidemiological surveillance continucs to be the most imponant aspect of attempts to monitor in fection control programmes, and to identify changes in risk factors that may increase the infection rate. Among the major challenges now facing the infection cont rol practitioner is the use of nosocomial infection ratcs as an indicator of quality of care. Awareness of infection statistics would servc as a stimulus to the prevention and control of infection, but would be useless if not accompanied by adequate systems to guarantce the comparability of data from different studies and centres. Suitably sensitive and specific surveillance systoms should be developed, and the use of site–specific and procedure–specific infection rates adjusted for the patient’s intrinsic risk should be encouraged.
Similar content being viewed by others
References
Gálves-Vargas R, Delgado-Rodrígun M, Guillén-Solvas JF. Concepto, importancia y futuro de la infección hospitalaria. In; Gálvez R, Delgado M, Guillén JF, editors. Infeccián Hospitalaria. Granada: University of Granada. 1993: 1–15
Brachman PS. Epidemiology of nosocomial infections. In:Bennet JV, Brachman PS, editors. Hospital Infections. Boston: Little, Brown and Co., 1992: 3–20
Thompson RL. SurveiIlance and reporting of nosocomial infections. In: Wenzel RP, editor. Prevention and control of nonsocomial infections. Baltimore: William and Wilkins, 1987: 70–82
Manian FA, Meyer L, Comprehensive surveillance of surgical wound infections in outpatient and inpatient surgery. Infect control Hosp Epidemiol 1990: 11: 515–20
Perl TM, Surveillance reporting and the use of computers. In: Wenzel RP, editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins, 1993: 139–76
Brown RB, Bradley S, Opitz E, et al. Surgical wound infection documented after hospital discharge. Am J Infect Control 1987: 15: 54–8
Holbrook KF, Nottebart VF, Hameed SR, et al. Automated postdischarge surveillance for postpartum and neonatal nosocomial infections. Am J Med 1991: 91 Suppl. 3B: 165–205
Centers for Disease Control (1973). Definitions used by the National Nosocomial lnfection Study. Quarterly report, Second quarter 1972
Garner JS, Jarvis WR, Emori TG, et al. CDC definitions for nosocomial infections. Am J Infect Control 1988: 16: 128–40
Haley RW, Quade D, Freeman H, et al. Appendix E. Algorithms for diagnosing infections. Am J Epidemiol 1980: 111: 635–43
Steering Group. National prevalence survey of hospital acquired infections: definitions. J Hosp Infect 1993: 24: 69–76
Haley RW, Culver DH, White JW, et al. The nationwide nosocomial infection rate: a new need for vital Statistics. Am J Epidemiol 1985; 121: 159–67
Ortona L, Federico G, Fantoni M, et al. A study on the: incidence of nosocomial infections in a large university hospital. Eur J Epidemiol 1985; 1: 94–9
Prat A, Asenjo MA, Canela J, et al. Estudio de la incidencia de Ia infección nosocomial. Rev San Hig Pub 1988: 62: 1765–73
CDC. Nosocomial infection rates for inter hospital comparison: limitations and possible solutions. Infec Conlrol Hosp Epidemiol 1991: 12: 609–21
Meers PD, Ayliffe GAJ, Emmerson AM, et al. Report on the national survey of infections in hospitals, 1980. J Hosp Infect 1981; 2 Suppl.: 1–51
Mertens R, Kegels G, Stroobant A, et al. The national prevalenec survey of nosocomial infections in Belgium, 1984. J Hosp Infect 1987: 9: 219–29
Moro ML, Stazi MA, Marasca D, et al. National prevalence survey of hospital–acquired infections in Italy, 1983. J Hosp Infect 1986; 8: 72–85
Jepsen OP, Mortensen N. Prevalence of nosocomial infections and infection control in Denmark. J Hosp Infect 1980: 1: 137–44
EPINE working group. Prevalence of hospital–acquired infections in Spain. J Hosp Infect 1992: 20: 1–13
Mayon-White RT, Ducel G, Kereselidze T, et al. An international survey of the prevalence of hospital–acquired infection. J Hosp Infect 1988: 11 Suppl. A: 43–8
Anderson LJ. Major trends in nosocomial virus infections. Am J Med 1991; 91 Suppl. 3B: 1075–115
Gaynes RP, Martone WJ, Culver DH, et al. Comparison of rates of nosocomial infections in neonatal intensive care units in the United States. Am J Med 1991: 91 Suppl. 31B: 1925–65
Delgado-Rodriguez M, Bueno-Cavanillas A, López-Gigosos R, et al. Hospital stay length as an effect modifier of other risk factor for nosocomial infection. Eur J Epidemiol 1990; 6: 34–9
Bueno-Cavanillas A, Rodriguez-Contreras R, Delgado-Rodriguez M, et al. Preoperative stay as a risk factor for nosocomial infection. Eur J Epidemiol 1991: 7: 670–6
Bueno-Cavanillaa A, Rodriguez R, Lopez-Luque A, et al. Usefulness of severity indices in intensive care medicine as a predictor of nosocomial infection risk. Intensive Care Med 1991; 17: 336–9
Britt MR, Schleupner CJ, Matsumiya S. Severity of underlying disease as a predictor of nosocomial infection; utility in the control of nosocomial infection. JAMA 1978; 329: 1047–51
Gross PA. Striving for Benchmark infection rates; progress in control for patient mix. Am J Med 1991; 91 Suppl 11; 16–20
Josephson A, Karanfil L, Alonso H, et al. Risk–specific nosocomial infection rates. Am J Med 1991; 91 Suppl. 11: 131–7
Wenzel RP, Osterman CA, Donowitz LG, et al. ldentification of procedure–related nosocomial infections in high–risk patients. Rev Infect Dis 1981: 3: 701–7
Jarvis WR, Edwards JR, Culver DH, et al. Nosocomial infection rates in adult and pediatric intensive care units in the United States. Am J Med 1991; 91 Suppl. 3B: 1855–915
Brown RB, Hosmer D, Chen HC, et al. A comparison of infections in different ICUs within the same hospital. Crit Care Med 1985; 13; 472–6
Constantini M, Dionisi PM, Turrin MG, et al. Hospital acquired infection surveillance and control in intensive care services. Results of an incidence study. Eur J Epidemiol 1987: 3: 347–55
Craven DE, Kunches LM, Lichtenberg DA, et al. Nosocomial infections and fatality in medical and surgical intensive care unit patients. Arch Intern Med 1988; 148: 1161–8
Daschner FD, Frey P, Wolff G, et al. Nosocomial infection in intensive care wards: a multicenter prospective study. Intensive Care Med 1982: 8: 5–9
Chandrasekar PH, Kruse JA, Matthews MF. Nosocomial infection among patients in different types of intensive care units at a city hospital. Crit Care Med 1986: 14: 508–10
Haley RW, Culver DH, Morgan WM, et al. Identifying patients at high risk of surgical wound infection: a sirnple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol 1985: 121; 206–15
Haley RW. Nosocomial infection in surgical patients: developing valid measures of intrinsic patients risk. Am J Med 1991; 91 Suppl. 3B: 1455–515
Freeman J, McGowan Jr JE. Risk factors for nosocomial infection. J Infect Dis 1978: 138: 811–9
Glenister HM, Taylor LJ, Barlett CLR, et al. An 11–month incidence study of infections in wards of a district general hospital. Infect Dis 1992: 21: 261–73
Haley RW, Culver DH, Morgan WM, et al. Increased recognition of infectious diseases in US hospitals through increased use of diagnostic tests, 1970–1976. Am J Epidemiol 1985; 121; 168–81
Bueno-Cavanillas A, Delgado-Rodriguez M, Cueto-Espinar A, et al. Vigilancia epidemiológica de la infección nosocomial. Rev Clin Esp 1987; 181: 92–7
Garcia-Martin M, Fernandez-Crehuet M, Galvez-Vargas R, Sistemas de vigilancia en la infección hospitalaria. In: Gálves R, Delgado M, Guillén JF, editors. Infección hospitalaria. Granada: University of Granada, 1993: 299–311
Glenister HM, Taylor LJ, Barlett CLR, et al. An assessment of selective surveillance methods for detecting hospital–acquired infecction. Am J Med 1991; 91 Suppl. 3B: 1215–45
Glenister HM, Taylor LJ, Barlett CLR, et al. An evaluation of surveillance methods for detecting infections in hospital inpatients. J Infect Dis 1993: 23: 229–42
Madison R, Afifi AA. Definition and comparability of nosocomial infection rates. Am J lnfect Control 1982; 10–49
Freeman J, McGowan JE. Methodologic issues in hospital epidemiology: I. Rates, case–finding and interpretation. Rev Infect Dis 1981: 3: 658–67
Rhame FS, Sudderth WD, Incidence and prevalence as used in the analysis of the occurrence of nosocomial infections. Am J Epidemiol 1981: 113: 1–11
Delgado-Rodriguez M, Sillero-Arenas M, Rodriguez-Contreras R, et al. Sobre la medición de la infección hospitalaria. Med Clin 1990; 94: 271–4
Freeman J, Hutchinson GB. Prevalence incidence and duration. Am J Epidemiol 1980: 112: 707–23
Larson E, Oram LF, Hedrick E. Nosocomial infections rates as an indicator of quality. Med Care 1988: 26: 676–84
Kazlauskas KL, Nadzam DM. The agenda for change: development of the Joint Commission infection Control Indicators. Infect Control Hosp Epidemiol 1992; 13: 331–5
Pfaller MA. Microbiology: the role of the clinical laboratory in hospital epidemiology and infection control. In: Wenzel RP, editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins, 1993: 385–405
Martone WJ, Jarvis WR, Culver DH. et al. Incidence and nature of endemic and epidemic nosocomial infections. In: Bennett JV, Brachman PS, editors. Hospital infections. Boston: Little, Brown and Co., 1992: 577–96
Eickhoff TC. Antibiotics and nosocomial infections. In: Bennet JV, Brachman PS, editors. Hospital infections. Boston: Little, Brown and Co., 1992: 245–64
Allen JR, Hightower AW, Martin SM, et al. Secular trends in nosocomial infections: 1970–1979. Am J Med 1981; 70; 389–92
McGowan Jr JE. Environmental factors in nosocomial infection: a seIective focus. Rev Infect Dis 1981; 3: 760–9
Pfaller MA. Opportunistic fungal infections: the increasing importance of Candida species. Infect Control Hosp Epidemiol 1989; 10: 270–3
Banerjee SN, Emori TG, Culver DH, et al. Secular trends in nosocomial primary bloodstream infections in the United States 1980–89. Am J Med 1991: 91 Suppl. 3B: 865–95
Schaberg DR, Culver DH, Gaynes RP. Major trend in microbial etiology of nosocomial infection. Am J Med 1991; 91 Suppl.3B: 725–55
Linnemann CC, Moore P, Staneck JL. Reemergence of epidemic methicillin–resistant Staphylococcus aureus in a general hospital associated With changing staphylococcal strains. Am J Med 1991. 91 Suppl. 3B: 2385–445
Bone RC. Gram–positive organisms and sepsis. Arch Intern Med 1994; 154: 26–34
Daschner F, editor. Proven and unproven methods in hospital infection control. Stuttgart: Gustav Fisher Verlag, 1978
Preston GA, Larson EL, Stamm WE. Effect of private isolation room on patient care practices: colonization and infection in an intensive care unit. Am J Med 1981: 70: 641–5
Kerver AJH, Rommes JH, Mevissen-Verhage EAE, et al. Colonization and infection in surgical intensive care patients: a prospective study. Intensive Care Med 1987: 13: 347–51
Millership SE, Patel N, Chattopadhyay B. Tile colonization of patients in an intensive treatment unit with gram–negative flora: the significance of oral route. J Hosp Infect 1986; 7: 226–35
Kerver AJH, Rommes JH, Mevissen-Verhage EAE. et al. Prevention of colonization and infection in critically ill patients: a prospective randomized study. Crit Care Med 1988: 16: 1087–93
Garner JS, Favero MS. Guideline for handwashing and hospital environmental control. Infect Control 1985: 7: 231–43
Larson E. A causal link between handwashing and risk of infection? Examination of the evidence. Infect Control Hosp Epidemiol 1998: 9: 28–36
Gamer JS. Hierholzer Jr WJ. Controversies in isolation politics and practices. In: Wenzel RP. editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins, 1993: 70–81
Slamm WE. Infections related to medical devices. Ann Intern Med 1978: 89: 764–9
Goldmann OA, Freeman J, Durbin Jr WA. Nosocomial infection and death in a neonatal intensive care unit. J Infect Dis, 1983: 147: 635–41
Neu HC. The patient at risk for infection: a summary. Am J Med 1984: 76: 240–3
Pennington JE. Respiratory tract infections: intrinsic risk factors. Am J Med 1984: 76: 34–41
Peterson PK. Host defense abnormalities predisposing the patient to infection. Am J Med 1984; 76, 2–10
Sobel JD, Kaye D. Host factors in the pathogenesis of urinary tract infections. Am J Med 1984: 76: 122–30
Emori TG, Banerjee SN, Culver DH. et al. Nosocomial infection in elderly patients in the United States, 1986–90. Am J Med 1991; 91 Suppl. 3B: 2895–935
Ayliffe GAJ. Nosocomial infection: the irreducible minimum. Infect Control 1986: 7 Suppl.: 92–95
Goldmann DA. Contemporary challenges for hospital epidemiology. Am J Med 1991: 91 Suppl. 3B: 85–155
Gross PA, Stein MR, Van Antwerpen C, et al. Comparison of severity of illness indicators in an intensive Care unit. Arch Intern Med 1991; 151; 2201–5
Keene AR, Cullen DJ. Therapeutic Intervention Score System: update 1983. Crit Care Med 1983: 11; 1–3
Knaus WA, Wagner DP, Draper EA, et al. APACHE II: a severity of disease classification syslem. Crit Care Med 1985; 13: 818–29
Gross PA, DeMauro PJ, Van Antwerpen C. et al. Number of comorbidities as a predictor of nosocomial infection acquisition. Infect Control Hosp Epidemiol 1988; 9: 497–500
Gross PA, Van Antwerpen C. Nosocomial infections and hospital deaths: a case–control study. Am J Med 1983: 75: 658–62
Bueno-Cavanillas A, Ramos-Cuadra A, Blanco-Jiménez JI. EI huésped, factores endógenos o intrinsicos. In: Gálvez R, Delgado M, Guillen JF, editors. Infeeción hospitalaria. Granada: University of Granada, 1993; 83–97
Bueno-Cavanillas A, Delgado-Rodriguez M, López-Luque A. et al. Influence of nosocomial infection on mortality rate in an intensive Care unit. Crit Care Med 1994: 22: 55–60
Garcia-Manin M, Delgado-Rodriguez M, Gómez-Olmedo M. EI huésped: factores exógenos. In: Galvez R, Delgado M, Guillen JF, editors. Infección hospitalaria. Granada: University of Granada, 1993: 99–111
Cross AS, Roup B. Role of respiratory assistance device in endemic nosocomial pneumonia. Am J Med 1981; 70: 681–5
Jiménez P, Turres A, Rudriguez-Roisin R, et al. Incidence of pneumonia acquired during mechanical ventilation. Crit Care Med 1989: 17: 882–5
Torres A, Aznar R, Gatell JM, et al. Incidence risk and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 1990: 142: 523–8
Levine SA, Niederman MS. The impact of tracheal intubation on host defenses and risks for nosocomial pneumonia. Clinics Chest Med 1991; 12: 523–43
Mountokalakis M, Skounakis M. Tselentis J. Short term versus prolonged systemic antibiotic prophylaxis in patients treated with indwelling catheters. J Urol 1985: 134: 506–8
Platt R, Polk BF, Murdock B, et al. Risk factors for nosocomial urinary tract infection. Am J Epidemiol 1986: 124: 977–85
Stamm WE. Catheter associated urinary tract infection: epidemiology pathogenesis and prevention. Am J Med 1991; 91 Suppl. 3B: 655–725
Garibaldi RA, Cushing D, Lerer T. Risk factors for postoperative infection. Am J Med 1991; 91 Suppl. 3B: 1585–635
Maki DG. Nosocomial bacteremia: an epidemiologic overview. Am J Med 1981: 70: 719–32
Maki DG. Infections due to infusion therapy. In: Bennett JV, Brachman PS, editors. Hospital infections. Boston: Little, Brown and Co., 1986: 561–80
Maki DG, Ringer M. Evaluation of dressing regimens for prevention of infection with peripheral intravenous catheters: gauze, a transparent polyurethane dressing and iodophortransparent dressing. JAMA 1987: 258: 2396–403
Hamory BH. Nosocomial bloodstream and intravascular device–related infections. In: Wenzel RP, editor. Prevention and control of nosocomial infections. Baltimore: Williams and Wilkins. 1987; 283–319
Armstrong CW, Mayhall CG, Miller KB, et al. Clinical predictors of infection of central venous catheters used for total parenteral nutrition. Infect Control Hosp Epidemiol 1990: 11; 71–8
Henderson DK. Bacteriemia debida a dispositivos intravasculares percutíneos. In: Mandell GL, Douglas Jr RG, Bennet JE, editors. Enfermedades infecciosas: principios y práctica. 3rd ed. Buenos Aires: Editorial Pananmericana, 1991
Korzeniowski OM. Effects of antibiotic on the mammalian immune system. Infect Dis Clin North Am 1989; 3; 469
Mandell LA. Effects of antimicrobial and antineoplastic drugs on the phagocylic and microbicidal function of the polymorphonuclear leukocyte. Rev Infect Dis 1982; 4: 683–97
McGowan Jr JE. Antimicrobial resistance in hospital organism and its relation to antibiotic use. Rev Infect Dis 1983: 5: 1033–48
Pitted D, Herwaldt LA, Massanari RM. The intensive care unit. In: Bennet JV, Brachman PS, editors. Hospital infections. Boston: Little, Brown and Co., 1992: 405–39
Maki DG. Risk factors for nosocomial infection in intensive care devices versus nature. Arch Intern Med 1989: 149: 30–5
Daschner F. Nosocomial infections in intensive care units. Intensive Care Med 1985: 11; 284–87
LaForce FM. The control of infections in hospitals: 1750 to 1950. In: Wenzel RP, editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins. 1993: 1–12
Haley RW, Culver DH, White JW, et al. The efficacy in infection surveillance and control programs in preventing nosocomial infections in US hospitals. Am J Epidemiol 1985: 121: 182–205
Scheckler WE. Surgeon–specific wound infection rates: a potentially dangerous and misleading strategy. Infect Control Hosp Epidemiol 1988: 9: 145–6
Brachman PS. Nosocomial infection surveillance. Infect Control Hosp Epidemiol 1993: 14: 194–6
Martone WJ. Year 2000 objectives for preventing nosocomial infections: how do we get there? Am J Med 1991: 91 Suppl.3B: 395–435
Brewer JH, Gasser CS. The affinity between continuous quality improvement and epidemic surveillance. Infect Control Hosp Epidemiol 1993: 14: 95–8
Bouza E, Cosin J, Grupo Cooperativo para eI Estudio de la lnfección. Estudio de prevalencia de infección hospitalaria y consumo de antimicrobianos. Med Clin 1986: 87: 353–8
Vaqué J, Rosello J, Campins M, et al. Prevalencia de infecciones en un hospital medico–quirurgico de tercer nivel: II. Uso de antibióticos. Med Clin 1987; 89: 362–5
Shapiro M, Townsend TR, Rosner B, et al. The use of antimicrobial drugs in general hospitals: patterns of prophylaxis. N Engl J Med 1979: 301; 351–5
Jackson GG. Considerations of antibiotic prophylaxis in non–surgical high risk patients. Am J Med 1981; 70: 467–73
DiNubile MJ. Antibiotics; the antipyrelics of choice? Am J Med 1990: 89: 787–8
Dunagan WC, Woodward RS, Medoff G, et al. Antimicrobial misuse in patients with positive blood culture. Am J Med 1989; 87: 253–9
Pallares R, Dick R, Wenzel RP, et aI. Trends in antimicrobial utilization at a tertiary teaching hospital during a 15–year period(1978–1992). lnfect Control Hosp Epidemiol 1993; 14; 376–82
Widdison AL, Pope NR, Brown EM. Survey of guidelines for antimicrobial prophylaxis in surgery. J Hosp infect 1993: 25: 199–205
Crossley K, Gardner LC. Antimicrobial prophylaxis in surgical patients. JAMA 1981: 245: 722–6
Classen DC, Scott R, Pestotnik SL, et al. The timing of prophylactic administration of antibiotics and the risk of surgical wound infection. N Engl J Med 1992; 326: 281–6
Ehrenkranz NJ. Antimicrobial prophylaxis in surgery: mechanisms, misconceptions and mischief. Infect Control Hosp Epidemiol 1993; 14: 99–106
Page CP, Bohnen JMA, Fletcher R, et al. Antimicrobial prophylaxis for surgical wounds: guidelines for clinical care. Arch Surg 1993: 128: 79–88
Van Scoy R, Wilkowske CJ, Prophylactic use of antimicrobial agents in adult patients. Mayo Clin Proc 1992; 67: 288–92
Wenzel RP. Preoperative antibiotic prophylaxis. N Engl J Med 1992; 326: 337–9
Trilla A, Mensa J. Perioperative antibiotic prophylaxis. In: Wenzel RP. editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins. 1993: 665–82
Dellinger EP, Gross PA, Barrett TL, et al. Quality standard for antimicrobial prophylaxis in surgical procedures. Infect Control Hosp Epidemiol 1994: 15: 182–8
Martin C. The French Study Group on Antimicrobial Prophylaxis in Surgery. The French Society of Anesthesia and Intensive Care. Antimicrobial prophylaxis in surgery: general concepts and clinical guidelines. Infect Control Hosp Epidemiol 1994: 15: 463–71
Stouttenbed CP, Van Saene HK, Miranda DR, et al. A new technique of infection prevention in the intensive care unit by selective decontamination of the digestive tract. Acta Anaesthesiol Belg 1983: 3: 209–21
Ledingham IMCA, Eastaway AT, McKey IC, et al. Triple regimen of selective decontamination of the intestine tract, systemic cefotaxime and microbiological surveillance for prevention of acquitance infection in intensive care. Lancet 1988: 1: 785–90
Van Saene HK, Stoutenbeek CP, Stoller JK. Selective decontamination of the digestive tract in the intensive care unit: current status and future prospects. Critical Med 1992: 20: 691–703
Sanderson PJ. Selective decontamination of the digestive tract: value in intensive care units not proved. BMJ 1989: 229: 1413–4
Vanderbroucke-Grauls CMJE, Vanderbroucke JP. Effects of the selective decontamination of the digestive tract on respiratory infections and mortality in the intensive care unit. Lancet 1991: 338: 859–62
Selective Decontamination of the Digestive Tract Trialists’ Collaborative Group. Meta–analysis of randomised controlled trials of selective decontamination of the digestive tract. BMJ 1993: 301: 525–32
First European Consensus Conference in Intensive Care Medicine. Selective decontamination of the digestive tract in intensive Care unit patient. Intensive Care Med 1992; 18: 182–8
Chaudhuri AK. Infection control in hospitals: has its quality–enhancing and cost–effective role been appreciated? J Hosp Infect 1993: 25: 1–6
Haley RW, Schaberg DR, Crossley KB, et al. Extracharges and prolongation of stay attributable to nosocomial infections: a prospective intehospital comparison. Am J Med 1981: 70: 51–8
Daschner F. The cost of hospital–acquired infection. J Hosp Infect 1984; 5 Suppl. A: 27–33
Diaz-Molina C. Garda-Martin M, Bueno-Cavanillas A, et al. Estimación del coste en una unidad de medicina intensiva. Med Clin 1993: 100: 329–32
Nettleman MD. The global impact of infection control. In: Wenzel RP, editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins. 1993: 13–20
Ehrenhranz NJ. Containing costs of antimicrobiaIs in the hospital: a critical evaluation. Am J Infect Control 1989: 17: 300–10
Wakefield DS, Helms CM, Massanari RM, et al. Cost of nosocomial infection: relative contribution of laboratory antibiotic and per diem costs in serious Staphylococcus aureus infections. Am J Infect Control 1988: 16: 185–92
WakefIeld DS, Pfaller M, Ludke RL, et al. Methods for estimating days of hospitalization due to nosocomial infections. Med Care 1992: 30: 313–6
Haley RW, Schaberg DR, Von Allmen SD, et al. Estimating the extra charges and prolongation of hospitalization due to nosocomial infections; a comparison of methods. J Infect Dis 1980: 141: 248–57
Haley RW. Measuring the costs of nosocomial infections: methods for estimating economic burden on the hospital. Am J Med 1991; 91 Suppl. 3B: 325–85
Freeman J, McGowan JE. Methodologic issues in hospital epidemiology: III. Investigating the modifying effects of time and severity underlying illness on estimates of cost of nosocomial infection. Rev Infect Dis 1984: 6: 285–300
Shulkin DJ, Kinosian B, Glick H, et al. The economic impact of infections: an analysis of hospital costs and charges in surgical patients with cancer. Arch Surg 1993: 128: 449–52
Wakefield DS, Nailer M, Hammons GT, et al. Use of the appropriateness evaluation protocol for estimating the incremental costs associated with nosocomial infections. Med Care 1987: 25: 481–8
Wakefield DS, Understanding the costs of nosocomial infections. In: Wenzel RP, editor. Prevention and control of nosocomial infection. Baltimore: Williams and Wilkins, 1993; 21–41
Freeman J, Rosner BA, McGowan Jr JE. Adverse effects of nosocomial infection. J Infect Dis 1979: 140: 732–40
Fabry J, Mcynel R, Joron MT. et al. Cost of nosocomial infections: analysis of 512 digestive surgery patients. World J Surg 1982: 6: 362–5
Haley RW. Cost–benefit analysis of infection control program. In: Bennet JV, Brachman PS, editors. Hospital infections. Boston: Little, Brown and Co., 1992: 507–32
Gross PA, Neu H, Van Antwerpen C. et al. Deaths from nosocomial infections: experience in a university hospital and community hospital. Am J Med 1980: 68: 219–23
Wenzel RP. The mortality of hospital–acquired bloodstream infections: need for a new vital statistic? Int J Epidemiol 1988: 17: 225–7
Rodrfguez G, Fernandez C, Delgado A. et al. Relación de la infección nosocomial con la mortalidad hospitalaria: estudio multicántrico. Med Clin 1993: 100: 9–13
Blanco-Jimenez JL, Lardelli-Claret P, Bueno-Cavanillas A. Epidemiologia descriptiva, criterios diagnósticos, morbilidad, mortalidad y coste. In: Galvez R, Delgado M, Guillán JF, editors. Infección hospitalaria. Granada: University of Granada, 1993: 113–36
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gálvez-Vargas, R., Bileno-Cavanillas, A. & García-Martín, M. Epidemiology, Therapy and Costs of Nosocomial Infection. Pharmacoeconomics 7, 128–140 (1995). https://doi.org/10.2165/00019053-199507020-00005
Published:
Issue Date:
DOI: https://doi.org/10.2165/00019053-199507020-00005