Sterile processing department (SPD) staff members have the difficult task of processing complicated instrumentation, containing costs, and managing limited resources; and how they face these challenges has a direct effect on patient care. Recent technological advances require SPD staff members to be more knowledgeable about what instrument trays are used together and the conditions in which they are used to help prevent costly delays in processing. This article explores how one health care system was successful in facing these challenges by implementing a solid orientation and education program.