Does medication adherence following a copayment increase differ by disease burden?

Health Serv Res. 2011 Dec;46(6pt1):1963-85. doi: 10.1111/j.1475-6773.2011.01286.x. Epub 2011 Jun 20.

Abstract

Objectives: To compare changes in medication adherence between patients with high- or low-comorbidity burden after a copayment increase.

Methods: We conducted a retrospective observational study at four Veterans Affairs (VA) medical centers by comparing veterans with hypertension or diabetes required to pay copayments with propensity score-matched veterans exempt from copayments. Disease cohorts were stratified by Diagnostic Cost Group risk score: low- (<1) and high-comorbidity (>1) burden. Medication adherence from February 2001 to December 2003, constructed from VA pharmacy claims data based on the ReComp algorithm, were assessed using generalized estimating equations.

Results: Veterans with lower comorbidity were more responsive to a U.S.$5 copayment increase than higher comorbidity veterans. In the lower comorbidity groups, veterans with diabetes had a greater reduction in adherence than veterans with hypertension. Adherence trends were similar for copayment-exempt and nonexempt veterans with higher comorbidity.

Conclusion: Medication copayment increases are associated with different impacts for low- and high-risk patients. High-risk patients incur greater out-of-pocket costs from continued adherence, while low-risk patients put themselves at increased risk for adverse health events due to greater nonadherence.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Antidepressive Agents / economics
  • Antidepressive Agents / therapeutic use
  • Antihypertensive Agents / economics
  • Antihypertensive Agents / therapeutic use
  • Comorbidity
  • Deductibles and Coinsurance / economics*
  • Depression / drug therapy
  • Depression / economics
  • Diabetes Mellitus / drug therapy
  • Health Services Research
  • Humans
  • Hypertension / drug therapy
  • Hypoglycemic Agents / economics
  • Hypoglycemic Agents / therapeutic use
  • Medication Adherence / statistics & numerical data*
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Socioeconomic Factors
  • United States
  • United States Department of Veterans Affairs

Substances

  • Antidepressive Agents
  • Antihypertensive Agents
  • Hypoglycemic Agents