Abstract
Monocytes are eliminated from cell culture by antigen or mitogen activated cytotoxic CD4+ T-lymphocytes. In this report we asked the question whether CD4+CD45RA+ and CD4+CD45RO+ subpopulations differ in the ability to kill monocytes in pokeweed mitogen (PWM)-activated cultures. Data are presented that although CD4+CD45RA+ vigorously proliferate in the presence of PWM, they do not kill monocytes or secrete IFN gamma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigen-Presenting Cells / immunology*
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Apoptosis
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / metabolism
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Cell Division
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Cells, Cultured
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Coculture Techniques
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Cytotoxicity, Immunologic*
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Humans
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Interferon-gamma / metabolism*
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Leukocyte Common Antigens / analysis*
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Lymphocyte Activation
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Monocytes / immunology*
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Pokeweed Mitogens / pharmacology
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T-Lymphocyte Subsets / drug effects
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
Substances
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Pokeweed Mitogens
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Interferon-gamma
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Leukocyte Common Antigens