In mammals, lipoxygenases catalyze the formation of hydroperoxides as the first step in the
biosynthesis of several inflammatory mediators. The substrate of this reaction, arachidonic …

Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger
triggering an interferon response. cGAMP is generated from GTP and ATP by cytoplasmic …

In mammals, the hydroperoxidation of arachidonic acid by lipoxygenases leads to the
formation of leukotrienes and lipoxins, compounds that mediate inflammatory responses …

Application of the concept of transient protectionto the synthesis of protected
deoxynucleosides is described. The deoxynucleosides are first treated with …

Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formation of the
metazoan second messenger c [G (2′, 5′) pA (3′, 5′) p], which binds the signaling …

Lipoxygenases catalyze the formation of fatty acid hydroperoxides, products used in further
biochemical reactions leading to normal and pathological cell functions. X-ray structure …

The effects of capacity fade, energy efficiency fade, failure rate, and charge/discharge profile
are investigated for lithium-ion (Li-ion) batteries based on first use in electric vehicles (EVs) …

We report a combined thermodynamic and structural characterization of a DNA tetraplex.
Using spectroscopic and calorimetric techniques, we demonstrate that d (TG3T) and d …

A third phase transition, centered at about 18 degrees C, was observed by differential
scanning calorimetry in a multilamellar suspension of dipalmitoyl phosphatidylcholine that …

An integrated set of reactions and conditions that allow an eight-step one-flask synthesis of
the protected derivatives of c-di-GMP and the [R p, R p] and [R p, S p] thiophosphate …