Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

LS Munoz-Price, L Poirel, RA Bonomo… - The Lancet infectious …, 2013 - thelancet.com
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in
1996. Since then, these versatile β-lactamases have spread internationally among Gram …

Beta-lactamases in laboratory and clinical resistance

DM Livermore - Clinical microbiology reviews, 1995 - Am Soc Microbiol
beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam
antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be …

CTX-M: changing the face of ESBLs in Europe

DM Livermore, R Canton, M Gniadkowski… - Journal of …, 2007 - academic.oup.com
Since around 2000—earlier in Poland and Spain and later in France and the UK—dramatic
shifts have occurred in the prevalence and types of extended-spectrum β-lactamases …

[HTML][HTML] Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

KK Kumarasamy, MA Toleman, TR Walsh… - The Lancet infectious …, 2010 - thelancet.com
Summary Background Gram-negative Enterobacteriaceae with resistance to carbapenem
conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health …

Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.

N Woodford, MJ Ellington, JM Coelho, JF Turton… - International journal of …, 2006 - Elsevier
Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and
is most often mediated by OXA carbapenemases. We describe a novel multiplex polymerase …

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study

TR Walsh, J Weeks, DM Livermore… - The Lancet infectious …, 2011 - thelancet.com
Background Not all patients infected with NDM-1-positive bacteria have a history of hospital
admission in India, and extended-spectrum β-lactamases are known to be circulating in the …

Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?

DM Livermore - Clinical infectious diseases, 2002 - academic.oup.com
Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella
pneumoniae, develops mutational resistance to cephalosporins less readily than …

[HTML][HTML] Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe

R Cantón, M Akóva, Y Carmeli, CG Giske… - Clinical microbiology …, 2012 - Elsevier
Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in
Europe in the 1990s, are now increasingly being identified at an alarming rate. Although …

The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

JF Turton, ME Ward, N Woodford… - FEMS microbiology …, 2006 - academic.oup.com
IS Aba1 was found in all widespread clones of Acinetobacter baumannii in the United
Kingdom. All isolates studied had a bla OXA-51-like carbapenemase gene; some also had …

Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae …

H Grundmann, C Glasner, B Albiger… - The Lancet infectious …, 2017 - thelancet.com
Background Gaps in the diagnostic capacity and heterogeneity of national surveillance and
reporting standards in Europe make it difficult to contain carbapenemase-producing …