The hair follicle, hair shaft, and sebaceous gland collectively form what is recognized as the
pilosebaceous unit. This complex, three-dimensional structure within the skin possesses a …

The FDA recently issued a guidance covering practices of scaleup and post approval
changes with semisolids (SUPAC-SS). This guidance outlines the steps that must be taken …

This Stimuli article provides general information about the test methods that should be
employed to ensure the quality and performance of topical and transdermal drug products …

Abstract Polyethylene glycols (PEGs) 600, 1000, and 2000 were used to study the molecular
weight permeability dependence in the rat nasal and gastrointestinal mucosa. Absorption of …

The permeation of fentanyl and sufentanil through cadaver skin membranes was
investigated using in vitro diffusion cell techniques. Neither drug influenced the permeation …

The 3-day AAPS/FDA Workshop on 'Bioequivalence of Topical Dermatological Dosage
Forms–Methods of Evaluating Bioequivalence', held on September 4–6, 1996 in Bethesda …

Results of permeation experiments involving finite dose diffusion cells with hairless mouse
skin as the membrane indicate that neither intact liposomes nor the phospholipid of which …

The physicochemical properties of select opioid and anilinopiperidine narcotic analgesics
were investigated. The solubilities of the narcotics in hexane and water and, for morphine, in …

Transdermal delivery of fentanyl from various adhesive matrix formulations to achieve a
steady‐state skin flux was investigated. For this purpose, various pressure‐sensitive …

A method to study the influence of hydration on skin permeability where the skin is immersed
in saline for up to 30 hr and under circumstances where a steady state rate of permeation …