The pancreas is an organ containing two distinct populations of cells, the exocrine cells that
secrete enzymes into the digestive tract, and the endocrine cells that secrete hormones into …

Engagement of integrin receptors with extracellular ligands gives rise to the formation of
complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton …

Stem Cells in Epithelial Tissues | Science news careers commentary Journals Science Science
Log in science science advances science immunology science robotics science signaling …

Mammalian cells proteolytically release (shed) the extracellular domains of many cell-
surface proteins1. Modification of the cell surface in this way can alter the cell's …

Observed climate change and variability (for definitions, see the IPCC Glossary, Appendix I)
are considered in this chapter by addressing seven commonly asked questions related to …

The ectodomains of numerous proteins are released from cells by proteolysis to yield
soluble intercellular regulators. The responsible protease, tumor necrosis factor-α converting …

BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in
patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic …

Some of the characteristics that complicate the analysis of water quality time series are non‐
normal distributions, seasonality, flow relatedness, missing values, values below the limit of …

The amyloid protein, Aβ, which accumulates in the brains of Alzheimer patients, is derived
by proteolysis of the amyloid protein precursor (APP). APP can undergo endoproteolytic …

Background Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) occur in 6 to
10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted …