Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
CA Dinarello, A Simon… - Nature reviews Drug …, 2012 - nature.com
Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …
[HTML][HTML] Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
[HTML][HTML] A guide to immunotherapy for COVID-19
FL van de Veerdonk, E Giamarellos-Bourboulis… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …
large body of literature has reported the effect of immune-based therapies in patients with …
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
E Tacconelli, E Carrara, A Savoldi… - The Lancet infectious …, 2018 - thelancet.com
Background The spread of antibiotic-resistant bacteria poses a substantial threat to
morbidity and mortality worldwide. Due to its large public health and societal implications …
morbidity and mortality worldwide. Due to its large public health and societal implications …
How should we define health?
M Huber, JA Knottnerus, L Green, H Van Der Horst… - Bmj, 2011 - bmj.com
The WHO definition of health as complete wellbeing is no longer fit for purpose given the
rise of chronic disease. Machteld Huber and colleagues propose changing the emphasis …
rise of chronic disease. Machteld Huber and colleagues propose changing the emphasis …
mTOR-and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Introduction Trained immunity refers to the memory characteristics of the innate immune
system. Memory traits of innate immunity have been reported in plants and invertebrates, as …
system. Memory traits of innate immunity have been reported in plants and invertebrates, as …
The effect of dietary supplementation with n—3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
S Endres, R Ghorbani, VE Kelley… - … England Journal of …, 1989 - Mass Medical Soc
We examined whether the synthesis of interleukin-1 or tumor necrosis factor, two cytokines
with potent inflammatory activities, is influenced by dietary supplementation with n—3 fatty …
with potent inflammatory activities, is influenced by dietary supplementation with n—3 fatty …
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity …
immunological imprinting of either tolerance (immunosuppression) or trained immunity …
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
J Kleinnijenhuis, J Quintin, F Preijers… - Proceedings of the …, 2012 - National Acad Sciences
Adaptive features of innate immunity, recently described as “trained immunity,” have been
documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show …
documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show …
[PDF][PDF] Trained immunity: a memory for innate host defense
MG Netea, J Quintin, JWM Van Der Meer - Cell host & microbe, 2011 - cell.com
Immune responses in vertebrates are classically divided into innate and adaptive, with only
the latter being able to build up immunological memory. However, although lacking adaptive …
the latter being able to build up immunological memory. However, although lacking adaptive …