Healthy vascular function is primarily regulated by several factors including EDRF
(endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) …

Studies of the coronary circulation have divided vascular resistances into three large
components: large vessels, small resistance vessels, and veins. Studies of the epicardial …

Despite abundant clinical evidence linking metabolic abnormalities to diabetic vasculopathy,
the molecular basis of individual susceptibility to diabetic vascular complications is still …

Objectives: This study sought to determine if simvastatin impairs exercise training
adaptations. Background: Statins are commonly prescribed in combination with therapeutic …

Cytochrome P450 epoxygenases convert arachidonic acid into 4 epoxyeicosatrienoic acid
(EET) regioisomers, which were recently identified as endothelium-derived hyperpolarizing …

Background—Angiotensin II (Ang II) contributes to vascular pathology in part by stimulating
NADPH oxidase activity, leading to increased formation of superoxide (O2−). We reported …

Background—Abdominal aortic aneurysms (AAAs) in humans are associated with locally
increased oxidative stress and activity of NADPH oxidase. We investigated the hypothesis …

Epoxyeicosatrienoic acids (EETs) are released from endothelial cells and potently dilate
small arteries by hyperpolarizing vascular myocytes. In the present study, we investigated …

Obesity and insulin resistance (IR) increase the risk for coronary heart disease; however,
much of this risk is not attributable to traditional risk factors. We sought to determine whether …

We hypothesized that the interaction between tumor necrosis factor-α (TNF-α)/nuclear factor-
κB (NF-κB) via the activation of IKK-β may amplify one another, resulting in the evolution of …