Pre-eclampsia

LC Chappell, CA Cluver, S Tong - The Lancet, 2021 - thelancet.com
Pre-eclampsia is a multisystem pregnancy disorder characterised by variable degrees of
placental malperfusion, with release of soluble factors into the circulation. These factors …

Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis

K Bramham, B Parnell, C Nelson-Piercy, PT Seed… - Bmj, 2014 - bmj.com
Objective To provide an accurate assessment of complications of pregnancy in women with
chronic hypertension, including comparison with population pregnancy data (US) to inform …

Evidence and recommendations on the use of telemedicine for the management of arterial hypertension: an international expert position paper

S Omboni, RJ McManus, HB Bosworth, LC Chappell… - …, 2020 - Am Heart Assoc
Telemedicine allows the remote exchange of medical data between patients and healthcare
professionals. It is used to increase patients' access to care and provide effective healthcare …

Effect of dexamethasone in hospitalized patients with COVID-19–preliminary report

P Horby, WS Lim, J Emberson, M Mafham, J Bell… - MedRxiv, 2020 - medrxiv.org
ABSTRACT Background Coronavirus disease 2019 (COVID-19) is associated with diffuse
lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing …

[HTML][HTML] Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

PW Horby, M Mafham, JL Bell, L Linsell, N Staplin… - The Lancet, 2020 - thelancet.com
Background Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the
basis of in vitro activity, preclinical studies, and observational studies. Here, we report the …

Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial

LC Chappell, PT Seed, AL Briley, FJ Kelly, R Lee… - The Lancet, 1999 - thelancet.com
Background Oxidative stress has been implicated in the pathophysiology of pre-eclampsia.
This randomised controlled trial investigated the effect of supplementation with vitamins C …

Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study

LC Chappell, S Duckworth, PT Seed, M Griffin… - Circulation, 2013 - Am Heart Assoc
Background—Hypertensive disorders of pregnancy are a major contributor to death and
disability for pregnant women and their infants. The diagnosis of preeclampsia by using …

[PDF][PDF] Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population‐based case‐control study

V Geenes, LC Chappell, PT Seed, PJ Steer… - …, 2014 - Wiley Online Library
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease,
characterized by maternal pruritus and raised serum bile acids. Our objectives were to …

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial

PW Horby, G Pessoa-Amorim, L Peto, CE Brightling… - Medrxiv, 2021 - medrxiv.org
Background Tocilizumab is a monoclonal antibody that binds to the receptor for interleukin
(IL)-6, reducing inflammation, and is commonly used to treat rheumatoid arthritis. We …

[HTML][HTML] Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data …

C Ovadia, PT Seed, A Sklavounos, V Geenes, C Di Ilio… - The Lancet, 2019 - thelancet.com
Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal
outcomes, but the association with the concentration of specific biochemical markers is …