User profiles for "author:M Jain"

Maneesh Jain

- Verified email at unmc.edu - Cited by 16052

Miten Jain

- Verified email at northeastern.edu - Cited by 11212

Mamta K. Jain

- Verified email at utsouthwestern.edu - Cited by 6403

Targeting the EGFR signaling pathway in cancer therapy

…, MP Ponnusamy, D Haridas, M Jain… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms

MK Jain, PM Ridker - Nature reviews Drug discovery, 2005 - nature.com
Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …

Should immunonutrition become routine in critically ill patients?: A systematic review of the evidence

DK Heyland, F Novak, JW Drover, M Jain, X Su… - Jama, 2001 - jamanetwork.com
ContextSeveral nutrients have been shown to influence immunologic and inflammatory
responses in humans. Whether these effects translate into an improvement in clinical …

The complete sequence of a human genome

…, M Haukness, K Howe, MW Hunkapiller, C Jain, M Jain… - Science, 2022 - science.org
Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

Tumour exosome integrins determine organotropic metastasis

…, MA Hollingsworth, M De Sousa, S Kaur, M Jain… - Nature, 2015 - nature.com
Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

…, PM Grandgenett, MA Hollingsworth, M Jain… - Nature cell …, 2015 - nature.com
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis,
mainly due to delayed detection. We hypothesized that intercellular communication is critical …

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo …

…, C Iastrebner, O Ioachimescu, M Jain… - The lancet Respiratory …, 2021 - thelancet.com
Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-
inflammatory properties. This study evaluates the efficacy and safety of baricitinib in …

[HTML][HTML] Baricitinib plus remdesivir for hospitalized adults with Covid-19

AC Kalil, TF Patterson, AK Mehta… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Severe coronavirus disease 2019 (Covid-19) is associated with
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …

[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers

…, M Berger, CM Rudin, DM Simeone, M Jain… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …

[HTML][HTML] An integrated cell atlas of the lung in health and disease

…, B Hooshiar Kashani, K Inecik, M Jain… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …