Targeting the EGFR signaling pathway in cancer therapy
…, MP Ponnusamy, D Haridas, M Jain… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
Anti-inflammatory effects of statins: clinical evidence and basic mechanisms
Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …
Multiple clinical studies have shown that a class of medications termed statins lower …
Should immunonutrition become routine in critically ill patients?: A systematic review of the evidence
DK Heyland, F Novak, JW Drover, M Jain, X Su… - Jama, 2001 - jamanetwork.com
ContextSeveral nutrients have been shown to influence immunologic and inflammatory
responses in humans. Whether these effects translate into an improvement in clinical …
responses in humans. Whether these effects translate into an improvement in clinical …
The complete sequence of a human genome
Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …
Tumour exosome integrins determine organotropic metastasis
Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
…, PM Grandgenett, MA Hollingsworth, M Jain… - Nature cell …, 2015 - nature.com
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis,
mainly due to delayed detection. We hypothesized that intercellular communication is critical …
mainly due to delayed detection. We hypothesized that intercellular communication is critical …
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo …
…, C Iastrebner, O Ioachimescu, M Jain… - The lancet Respiratory …, 2021 - thelancet.com
Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-
inflammatory properties. This study evaluates the efficacy and safety of baricitinib in …
inflammatory properties. This study evaluates the efficacy and safety of baricitinib in …
[HTML][HTML] Baricitinib plus remdesivir for hospitalized adults with Covid-19
Abstract Background Severe coronavirus disease 2019 (Covid-19) is associated with
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …
detection. We investigated the proteomic profile of extracellular vesicles and particles …
[HTML][HTML] An integrated cell atlas of the lung in health and disease
…, B Hooshiar Kashani, K Inecik, M Jain… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …